Evidence map›Paper›PMID 41565477›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2026

Molecular Signatures of Id2- and Ascl4-Induced Wiring of Adult Hippocampal Neurons.

Charlotte Seng, Bálint Tamás, Rashmit Kaur, Wenshu Luo, Csaba Földy

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Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

5 authors.

Charlotte SengLaboratory of Neural Connectivity, Brain Research Institute, Faculties of Medicine and Science, University of Zürich, Zürich 8057, Switzerland.
Bálint TamásLaboratory of Neural Connectivity, Brain Research Institute, Faculties of Medicine and Science, University of Zürich, Zürich 8057, Switzerland.
Rashmit KaurLaboratory of Neural Connectivity, Brain Research Institute, Faculties of Medicine and Science, University of Zürich, Zürich 8057, Switzerland.
Wenshu LuoLaboratory of Neural Connectivity, Brain Research Institute, Faculties of Medicine and Science, University of Zürich, Zürich 8057, Switzerland.
Csaba FöldyLaboratory of Neural Connectivity, Brain Research Institute, Faculties of Medicine and Science, University of Zürich, Zürich 8057, Switzerland foldy@hifo.uzh.ch.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

While circuit formation is generally thought to be absent in the adult brain, there is evidence that the adult brain retains a considerable capacity for neuronal wiring. Among other findings, molecular programming by basic helix-loop-helix (bHLH) proteins can reactivate axon growth in adult neurons, allowing the investigation of the mechanisms and potential of adult brain rewiring. Here, we analyzed proteomic and transcriptomic changes during Id2-induced (a bHLH transcriptional regulator) and Ascl4-induced (a bHLH transcription factor) feedback and feedforward wiring in the hippocampus of adult male and female mice. We find that Id2 and Ascl4 share a molecular cascade through the transcription factor Stat1 and coregulate a set of proteins that may constitute a core program for adult wiring. Unexpectedly, we also identify shared molecular changes that do not originate directly from the programmed neurons, but from endothelial cells and microglia. Taken together, our results suggest that adult brain wiring is regulated by specific molecular programs and dynamic interactions between the wiring neurons and the circuit environment.

Indexed as

Basic Helix-Loop-Helix ProteinsHippocampusInhibitor of Differentiation Protein 2NeuronsAnimalsFemaleMaleMiceMice, Inbred C57BLAscl1 protein, mouseBasic Helix-Loop-Helix ProteinsIdb2 protein, mouseInhibitor of Differentiation Protein 2adult brain wiringAscl4circuit formationId2molecular programmingStat1

Identifiers

PMID41565477
PMCPMC12925661

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.