Evidence map›Paper›PMID 41564576›Full record

ArticleNeurobiology of aging2026

Concurrent associations between visit-to-visit changes in actigraphy-based physical activity and cognitive aging in older adults.

Ranjani P Shankar, Rowan Saloner, Coty Chen, Claire Cadwallader, Anna M VandeBunte, Valentina Diaz, Lana Callies, Carina Lo, Sophia Licata, Jessica Buxton and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Ranjani P ShankarDepartment of Neurology, Edward and Pearl Fein Memory and Aging Center, University of California, Weill Institute for Neurosciences, San Francisco, CA, USA.
Rowan SalonerDepartment of Neurology, Edward and Pearl Fein Memory and Aging Center, University of California, Weill Institute for Neurosciences, San Francisco, CA, USA.
Coty ChenDepartment of Neurology, Edward and Pearl Fein Memory and Aging Center, University of California, Weill Institute for Neurosciences, San Francisco, CA, USA.
Claire CadwalladerDepartment of Neurology, Edward and Pearl Fein Memory and Aging Center, University of California, Weill Institute for Neurosciences, San Francisco, CA, USA.
Anna M VandeBunteDepartment of Neurology, Edward and Pearl Fein Memory and Aging Center, University of California, Weill Institute for Neurosciences, San Francisco, CA, USA.
Valentina DiazDepartment of Neurology, Edward and Pearl Fein Memory and Aging Center, University of California, Weill Institute for Neurosciences, San Francisco, CA, USA.
Lana CalliesDepartment of Neurology, Edward and Pearl Fein Memory and Aging Center, University of California, Weill Institute for Neurosciences, San Francisco, CA, USA.
Carina LoDepartment of Neurology, Edward and Pearl Fein Memory and Aging Center, University of California, Weill Institute for Neurosciences, San Francisco, CA, USA.
Sophia LicataDepartment of Neurology, Edward and Pearl Fein Memory and Aging Center, University of California, Weill Institute for Neurosciences, San Francisco, CA, USA.
Jessica BuxtonDepartment of Neurology, Edward and Pearl Fein Memory and Aging Center, University of California, Weill Institute for Neurosciences, San Francisco, CA, USA.
Albert PhamDepartment of Neurology, Edward and Pearl Fein Memory and Aging Center, University of California, Weill Institute for Neurosciences, San Francisco, CA, USA.
Molly OlzinskiDepartment of Neurology, Edward and Pearl Fein Memory and Aging Center, University of California, Weill Institute for Neurosciences, San Francisco, CA, USA.
Yann CobigoDepartment of Neurology, Edward and Pearl Fein Memory and Aging Center, University of California, Weill Institute for Neurosciences, San Francisco, CA, USA.
Adam M StaffaroniDepartment of Neurology, Edward and Pearl Fein Memory and Aging Center, University of California, Weill Institute for Neurosciences, San Francisco, CA, USA.
Gil D RabinoviciDepartment of Neurology, Edward and Pearl Fein Memory and Aging Center, University of California, Weill Institute for Neurosciences, San Francisco, CA, USA.
Joel H KramerDepartment of Neurology, Edward and Pearl Fein Memory and Aging Center, University of California, Weill Institute for Neurosciences, San Francisco, CA, USA.
Kaitlin B CasalettoDepartment of Neurology, Edward and Pearl Fein Memory and Aging Center, University of California, Weill Institute for Neurosciences, San Francisco, CA, USA.
Emily W PaolilloDepartment of Neurology, Edward and Pearl Fein Memory and Aging Center, University of California, Weill Institute for Neurosciences, San Francisco, CA, USA. Electronic address: Emily.Paolillo@ucsf.edu.

Funding

Research Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Gil Dan Rabinovici · 2019 to 2026
$36.9M
Mechanisms of Executive Decline in Normal AgingR01AG032289 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Kaitlin B Casaletto, JOEL H KRAMER · 2009 to 2026
$8.3M
Unraveling the intersection of synaptic biology, lifestyle, and cognitive resilienceR01AG072475 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CASALETTO, KAITLIN B · 2021 to 2025
$4.3M
Effects of chronic inflammation on brain structure and functionR01AG048234 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRAMER, JOEL H · 2015 to 2019
$3.2M
Novel Imaging and Biofluid Biomarkers of Small Vessel Cerebrovascular DiseaseUF1NS100608 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRAMER, JOEL H · 2021 to 2021
$2.5M
Can Behavior Shape Neural Health? Identifying Modifiable Factors to Prevent Cognitive Decline in AgeK23AG058752 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CASALETTO, KAITLIN B · 2018 to 2022
$994k
Passive digital phenotyping for capturing real-world neurobehavior in neurodegenerative diseaseK23AG084883 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Emily Paolillo · 2024 to 2026
$592k
Deciphering the molecular landscape of frontotemporal lobar degeneration: A network-based proteomic approachK23AG090757 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Rowan Saloner · 2025 to 2026
$400k
NIA NIH HHS K23 AG058752NIA NIH HHS K23 AG084883NIA NIH HHS K23 AG090757NIA NIH HHS P30 AG062422NIA NIH HHS R01 AG032289NIA NIH HHS R01 AG048234NIA NIH HHS R01 AG072475NINDS NIH HHS UF1 NS100608
6 · The paper itself

Abstract

Physical activity (PA) is associated with lower dementia risk, yet few studies examine objectively measured PA with concurrently measured brain and cognitive aging outcomes longitudinally, leaving a gap in knowledge regarding temporality of these brain-behavior associations. We examined how longitudinal within-person changes in average daily step count track with changes in memory, executive function, hippocampal volumes, white matter hyperintensities (WMH), and depressive symptoms over time. 107 older adults completed neuropsychological testing and brain magnetic resonance imaging, followed by 30-day Fitbit monitoring at two or more annual study visits at the UCSF Memory and Aging Center. Linear mixed-effects models examined each brain health outcome as a function of visit-to-visit PA, time (years since baseline), baseline age, sex, education, and total intracranial volume (neuroimaging models only). Within-person increases in daily step count were most strongly associated with within-person increases in executive functioning (Std. β = 0.128, 95 %CI [0.056, 0.200], p ≤ 0.001) and decreases in depressive symptoms (Std. β = -0.201, 95 %CI [-0.284, -0.119], p ≤ 0.001). Longitudinal PA associations with memory, hippocampal volumes, and WMH did not reach statistical significance. Findings suggest that within-person changes in PA may reduce real-time risk of cognitive decline; additionally, real-world monitoring of movement via actigraphy may be sensitive to early and subtle aspects of neurobehavioral declines with aging.

Indexed as

ActigraphyAgingCognitive AgingExerciseAgedAged, 80 and overBrainDepressionExecutive FunctionFemaleHippocampusHumansLongitudinal StudiesMagnetic Resonance ImagingMaleMemoryDigitalExerciseLifestyleModifiableNeuroimagingNeuropsychologyWearable

Identifiers

PMID41564576
PMCPMC13081761

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.