ReviewJournal of medicinal chemistry2026
Metabolic Stability of Fluorinated Small Molecules: A Physical Organic Chemistry Perspective.
Review in Journal of medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Unique fluoroalkyl substituents: is there life after CFChemical science · 2026Review
- Direct Regioselective para-Fluorination via I(I)/I(III) Catalysis.Angewandte Chemie (International ed. in English) · 2026Article
- Design, synthesis, and biological evaluation of novel trifluoromethyl-substituted quinolinone derivatives targeting triple-negative breast cancer.Molecular diversity · 2026Article
- Active-site recognition enables hydroxylation of a fluorine-deactivated C-H bond in 6,6,6-trifluoro-L-norleucine.Chemical communications (Cambridge, England) · 2026Article
- A Ni-Mediated Cross-Coupling Approach to DeuteratedJournal of the American Chemical Society · 2026Article
- Discovery ofJournal of medicinal chemistry · 2026Article
- Efficient One-Pot Functionalization of Pyrroles via Dearomative Chlorination-Thiocyanation Strategy.International journal of molecular sciences · 2026Article
- Special Issue "Heterocyclic Compounds: Synthesis, Design, and Biological Activity".International journal of molecular sciences · 2026Article
- The Effect ofACS medicinal chemistry letters · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The incorporation of fluorine and fluorinated motifs into medicinally relevant scaffolds can improve the metabolic and pharmacokinetic properties (DMPK) of drug molecules. Typically, this phenomenon is attributed to differences in C-H vs C-F bond strengths, though such an explanation ignores accepted mechanisms of drug metabolism and how fluorine and fluorinated substituents perturb the physicochemical properties of small molecules. Instead of relying on bond strengths, this perspective will review established mechanisms of drug metabolism and provide a mechanistic rationale for the improved metabolic profiles achieved by fluorinating drug candidates. This discussion will connect observed trends in structure-metabolism relationships with known mechanistic features of relevant drug-metabolizing enzymes, with the ultimate goal of improving medicinal chemistry decision-making.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.