Evidence map›Paper›PMID 41564171›Full record

ArticleScience advances2026

A genome-wide genetic screen reveals the P2Y2-integrin axis as a stabilizer of EGFR mutants in non-small cell lung cancer (NSCLC).

Yafei Du, Wenjing Wang, Hui Chin Goh, Thamil Selvan Vaiyapuri, Anandhkumar Raju, Yu-Chun Hsiao, Cheng Chun Wang, Vanisha Agrawal, Noorul Farzana Mohideen, Norhidayah Binte Mohd Mazian and 13 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Yafei DuInstitute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), 61 Biopolis Drive, Proteos, Singapore 138673, Singapore.ORCID 0000-0003-3926-8461
Wenjing WangInstitute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), 61 Biopolis Drive, Proteos, Singapore 138673, Singapore.ORCID 0000-0003-0408-6764
Hui Chin GohInstitute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), 61 Biopolis Drive, Proteos, Singapore 138673, Singapore.
Thamil Selvan VaiyapuriInstitute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), 61 Biopolis Drive, Proteos, Singapore 138673, Singapore.ORCID 0009-0003-6626-4519
Anandhkumar RajuInstitute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), 61 Biopolis Drive, Proteos, Singapore 138673, Singapore.ORCID 0009-0002-0389-9384
Yu-Chun HsiaoCenter for Molecular Medicine, Research Center for Cancer Biology, and Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.
Cheng Chun WangInstitute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), 61 Biopolis Drive, Proteos, Singapore 138673, Singapore.ORCID 0009-0002-2960-7562
Vanisha AgrawalInstitute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), 61 Biopolis Drive, Proteos, Singapore 138673, Singapore.ORCID 0009-0009-3803-2255
Noorul Farzana MohideenInstitute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), 61 Biopolis Drive, Proteos, Singapore 138673, Singapore.
Norhidayah Binte Mohd MazianInstitute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), 61 Biopolis Drive, Proteos, Singapore 138673, Singapore.ORCID 0009-0000-1398-270X
Feride KaratekinInstitute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), 61 Biopolis Drive, Proteos, Singapore 138673, Singapore.ORCID 0009-0009-5430-429X
Wendy Kehan WangInstitute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), 61 Biopolis Drive, Proteos, Singapore 138673, Singapore.
Manikandan LakshmananInstitute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), 61 Biopolis Drive, Proteos, Singapore 138673, Singapore.ORCID 0000-0001-5103-3054
Komal GuptaInstitute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), 61 Biopolis Drive, Proteos, Singapore 138673, Singapore.
Han ChangSchool of Medicine, China Medical University, Taichung, Taiwan.
Xavier Le GuezennecInstitute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), 61 Biopolis Drive, Proteos, Singapore 138673, Singapore.ORCID 0000-0002-1590-1325
Frederic BardInstitute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), 61 Biopolis Drive, Proteos, Singapore 138673, Singapore.ORCID 0000-0002-3783-4805
Daniel S W TanNational Cancer Centre Singapore, 11 Hospital Crescent, Singapore 169610, Singapore.
Vinay TergaonkarInstitute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), 61 Biopolis Drive, Proteos, Singapore 138673, Singapore.ORCID 0000-0001-9009-0844
Mien-Chie HungCenter for Molecular Medicine, Research Center for Cancer Biology, and Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.ORCID 0000-0003-4317-4740
Xiaogang LiuDepartment of Chemistry, National University of Singapore, Singapore, Singapore.ORCID 0000-0003-2517-5790
Wanjin HongInstitute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), 61 Biopolis Drive, Proteos, Singapore 138673, Singapore.ORCID 0000-0002-1719-8960
Gandhi T K BoopathyInstitute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A∗STAR), 61 Biopolis Drive, Proteos, Singapore 138673, Singapore.ORCID 0000-0002-1821-9540

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Activating mutations in the epidermal growth factor receptor (

Indexed as

Carcinoma, Non-Small-Cell LungIntegrin beta1Lung NeoplasmsMutationReceptors, Purinergic P2Y2Adenosine TriphosphateCell Line, TumorErbB ReceptorsGene Expression Regulation, NeoplasticGenetic TestingHumansPhosphorylationRNA InterferenceSignal TransductionAdenosine TriphosphateEGFR protein, humanErbB ReceptorsIntegrin beta1P2RY2 protein, humanReceptors, Purinergic P2Y2

Identifiers

PMID41564171
PMCPMC12822653

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.