Evidence map›Paper›PMID 41564131›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

α2-macroglobulin function of thioester-containing proteins guards

Chuping Cai, Adrian Acker, Jianqiong Huang, Yingying Liu, Maria Victoria Molino, Javier F Mariscotti, Eleonora Garcia-Véscovi, Philippe Bulet, Philippe Hammann, Johana Chicher and 5 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Macrophage restriction inScience advances · 2026
    Article
  2. α2-macroglobulin function of thioester-containing proteins guardsProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Chuping CaiSino-French Hoffmann Institute, Guangzhou Medical University, Guangzhou 511436, China.
Adrian AckerFaculté des Sciences de la Vie, Université de Strasbourg, Strasbourg 67000, France.
Jianqiong HuangSino-French Hoffmann Institute, Guangzhou Medical University, Guangzhou 511436, China.ORCID 0000-0003-1048-9164
Yingying LiuSino-French Hoffmann Institute, Guangzhou Medical University, Guangzhou 511436, China.
Maria Victoria MolinoLaboratorio de Patogénesis Bacteriana, Instituto de Biología Molecular y Cellular de Rosario, Consejo Nacional de Investigaciones Cientificas y Tecnológicas, Universidad Nacional de Rosario, Rosario 2000, Argentina.
Javier F MariscottiLaboratorio de Patogénesis Bacteriana, Instituto de Biología Molecular y Cellular de Rosario, Consejo Nacional de Investigaciones Cientificas y Tecnológicas, Universidad Nacional de Rosario, Rosario 2000, Argentina.
Eleonora Garcia-VéscoviLaboratorio de Patogénesis Bacteriana, Instituto de Biología Molecular y Cellular de Rosario, Consejo Nacional de Investigaciones Cientificas y Tecnológicas, Universidad Nacional de Rosario, Rosario 2000, Argentina.ORCID 0000-0002-4431-8606
Philippe BuletUniversité Grenoble Alpes, Institute for Advanced Biosciences, INSERM U1209, CNRS, UMR 5309, Grenoble 38000, France.ORCID 0000-0001-9016-265X
Philippe HammannUniversité de Strasbourg, CNRS, Plateforme Protéomique Strasbourg-Esplanade, Strasbourg 67000, France.
Johana ChicherUniversité de Strasbourg, CNRS, Plateforme Protéomique Strasbourg-Esplanade, Strasbourg 67000, France.ORCID 0000-0002-4403-7484
Samuel LiegeoisSino-French Hoffmann Institute, Guangzhou Medical University, Guangzhou 511436, China.
Zi LiSino-French Hoffmann Institute, Guangzhou Medical University, Guangzhou 511436, China.
Jules A HoffmannSino-French Hoffmann Institute, Guangzhou Medical University, Guangzhou 511436, China.
Nicolas MattFaculté des Sciences de la Vie, Université de Strasbourg, Strasbourg 67000, France.ORCID 0000-0003-0323-1851
Dominique FerrandonSino-French Hoffmann Institute, Guangzhou Medical University, Guangzhou 511436, China.ORCID 0000-0001-7680-7773

Funding

111 Plan | Overseas Expertise Introduction Project for Discipline Innovation D18010ECOS-SUD (#A12B04EUR IMCBio ANR-17-EURE-0023IDEX Unistra ANR-10-IDEX-0002Natural Science Foundation of China 32370931SFRI STRAT'US Project ANR 20-SFRI-0012
6 · The paper itself

Abstract

RNAseq analysis of the

Indexed as

alpha-MacroglobulinsBacterial ProteinsDrosophilaDrosophila melanogasterDrosophila ProteinsAnimalsPeptidesPseudomonas aeruginosaSerratia marcescensalpha-MacroglobulinsBacterial ProteinsDrosophila ProteinsPeptidesthioester-containing protein-4, Drosophilahost defense micropeptidesinnate immunitylncRNAsprotease inhibitor function modulationresilience/disease tolerance

Identifiers

PMID41564131
PMCPMC12846816

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.