Evidence map›Paper›PMID 41564041›Full record

ArticlePloS one2026

Effects of intermittent hypoxia on adipose-derived mesenchymal stem cells in protecting alveolar type II cells from injury.

RuiYin Lai, SuHeng Chen, JunJie Cui, XiaoLong Liu, YuLan Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

RuiYin LaiThe First School of Clinical Medicine, Lanzhou University, Gansu, Lanzhou, China.
SuHeng ChenThe First School of Clinical Medicine, Lanzhou University, Gansu, Lanzhou, China.
JunJie CuiThe First School of Clinical Medicine, Lanzhou University, Gansu, Lanzhou, China.
XiaoLong LiuThe First School of Clinical Medicine, Lanzhou University, Gansu, Lanzhou, China.
YuLan LiThe First Hospital of Lanzhou University, Gansu, Lanzhou, China.ORCID https://orcid.org/0009-0009-2852-7799

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adipose-derived mesenchymal stem cells (ADSCs) have demonstrated significant therapeutic effects on acute lung injury. Numerous studies have reported that preconditioning ADSCs can enhance their therapeutic efficacy. Currently, there is a lack of research on intermittent hypoxia preconditioning of ADSCs. In this study, we subjected ADSCs to intermittent hypoxic preconditioning, followed by the detection of their expressions of HIF-1α, HGF, VEGF, and IL-10. We also evaluated the therapeutic effects of ADSCs on oxidative stress and cell apoptosis in LPS-induced MLE-12 cells, and compared the outcomes resulting from different types of hypoxic preconditioning. Finally, we concluded that Intermittent hypoxia preconditioning leads to decrease in the secretion of VEGF by ADSCs compared to sustained hypoxia preconditioning; but their therapeutic effects in terms of anti-apoptosis and anti-oxidation are comparable.

Indexed as

Adipose TissueAlveolar Epithelial CellsMesenchymal Stem CellsAnimalsApoptosisCell HypoxiaCell LineHepatocyte Growth FactorHypoxia-Inducible Factor 1, alpha SubunitInterleukin-10LipopolysaccharidesMiceOxidative StressVascular Endothelial Growth Factor AHepatocyte Growth FactorHypoxia-Inducible Factor 1, alpha SubunitInterleukin-10LipopolysaccharidesVascular Endothelial Growth Factor A

Identifiers

PMID41564041
PMCPMC12822967

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.