ArticleJournal of clinical gastroenterology2026
Disability and Health Care Interactions in Patients with Celiac Disease in the United States: An Analysis of All of Us Cohort.
Bettina Anil, Jonathan Govrin, Duojian Kongcao, Hemanth Karnati, Peter H R Green, Xiao-Fei Kong, Benjamin Lebwohl
Abstract read
In one paragraphArticle in Journal of clinical gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
7 authors.
Bettina AnilDivision of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX.ORCID 0009-0008-2901-5405 Jonathan GovrinDivision of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX.
Duojian KongcaoDivision of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX.
Hemanth KarnatiDivision of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX.
Peter H R GreenCeliac Disease Center, Columbia University, New York, NY.
Xiao-Fei KongDivision of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX.
Benjamin LebwohlCeliac Disease Center, Columbia University, New York, NY.
Funding
Technology to Empower Changes in Health (TECH) Network Participant Technologies CenterU24OD023176 · OD · SCRIPPS RESEARCH INSTITUTE, THE · PI TOPOL, ERIC JEFFREY · 2016 to 2022
$204.7MPrecision Medicine Initiative Cohort Program BiobankU24OD023121 · OD · MAYO CLINIC ROCHESTER · PI CEKANOVA, MARIA, CICEK, MINE · 2016 to 2024
$185.5MEnhancing All of Us Data Resources for Nutrition Precision Health: the All of Us Data and Research CenterU2COD023196 · OD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GLAZER, DAVID, HARRIS, PAUL A. · 2016 to 2022
$143.7MAdaptive Platform for Personalized EngagementU24OD023163 · OD · VIGNET, INC. · PI JAIN, PRADUMAN · 2017 to 2020
$102.6MUniversity of Arizona-Banner Health All of Us Research Program OT2OD026549 · OD · UNIVERSITY OF ARIZONA · PI MORENO, FRANCISCO A, REIMAN, ERIC MICHAEL · 2018 to 2023
$78.9MCalifornia Precision Medicine Research Program ConsortiumOT2OD026552 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANTON-CULVER, HODA A, OHNO-MACHADO, LUCILA · 2018 to 2023
$73.4MAll of Us PennsylvaniaOT2OD026554 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E, VISWESWARAN, SHYAM · 2018 to 2023
$72.1MNew York City Consortium for Precision MedicineOT2OD026556 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BIER, LOUISE E, GHARAVI, ALI G · 2018 to 2023
$67.3MSouthEast Enrollment Center (SEEC) OT2OD026551 · OD · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CARRASQUILLO, OLVEEN, COLON, VIVIAN · 2018 to 2023
$62.8MSouthern All of Us NetworkOT2OD026548 · OD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI FOUAD, MONA N., KORF, BRUCE R · 2018 to 2023
$60.5MIllinois Precision Medicine Consortium OT2OD026557 · OD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI AHSAN, HABIBUL, ARGOS, MARIA · 2018 to 2023
$60.5MThe New England Precision Medicine Consortium of the All of Us Research ProgramOT2OD026553 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CLARK, CHERYL RENEE, KARLSON, ELIZABETH W · 2018 to 2023
$58.8MNIDDK NIH HHS K08 DK128631NIDDK NIH HHS R03 DK144282NIH HHS OT2 OD023205NIH HHS OT2 OD023206NIH HHS OT2 OD025276NIH HHS OT2 OD025277NIH HHS OT2 OD025315NIH HHS OT2 OD025337NIH HHS OT2 OD026548NIH HHS OT2 OD026549NIH HHS OT2 OD026550NIH HHS OT2 OD026551NIH HHS OT2 OD026552NIH HHS OT2 OD026553NIH HHS OT2 OD026554NIH HHS OT2 OD026555NIH HHS OT2 OD026556NIH HHS OT2 OD026557NIH HHS U24 OD023121NIH HHS U24 OD023163NIH HHS U24 OD023176NIH HHS U2C OD023196
6 · The paper itselfAbstract
BACKGROUNDS AND
aimsCeliac disease (CeD) presents with various gastrointestinal and systemic comorbidities, causing significant social and health burdens. Given the substantial symptom burden and lack of therapeutic options beyond the gluten-free diet, patients with CeD may have limited or unsatisfying interactions with healthcare providers.
methodsUsing the All of Us Research Program, we analyzed five categories of surveys: basic, lifestyle, overall health, social factors of health, and healthcare access and utilization, for participants with self-reported or electronic health records-documented CeD. To increase diagnostic accuracy, we excluded CeD patients without compatible HLA haplotypes or with a polygenic risk score associated with a low probability of CeD. Each patient with CeD was matched to cohort participants without CeD using the following matching parameters: age, genetically inferred ancestry, and sex.
resultsIndividuals with CeD (n=1816) were more likely to report severe fatigue (12.0% vs. 8.4%), frequent specialist visits (≥13 per year: 6.6% vs. 4.3%), and negative interactions with healthcare. On multivariate logistic regression, the following symptoms and healthcare interactions were independently associated with CeD: fatigue severity (OR=1.19, 95% CI [1.11-1.27]), more frequent medical specialist visits OR=1.69, 95% CI: 1.51-1.90, and negative provider interactions were all positively associated with increased likelihood of CeD.
conclusionsParticipants with CeD reported significantly greater functional limitations, higher difficulty assessing care, and a higher degree of fatigue, compared to participants without CeD, underscoring the need to integrate social determinants of health and patient-reported experiences into clinical management.
Indexed as
celiac diseasedisabilitydisparitiesfatiguepatient-reported outcomes
Identifiers
PMID41564024
PMCPMC13459507
What OpenQuestion holds
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