Evidence map›Paper›PMID 41564010›Full record

ArticleBJS open2025

Assessing complications following pancreatoduodenectomy: the Comprehensive Complication Index versus the Clavien-Dindo classification.

Kristjan Ukegjini, José Oberholzer, Philip C Müller, Rene Warschkow, Ignazio Tarantino, Jan Philipp Jonas, Marie Klein, Henrik Petrowsky, Bruno M Schmied, Thomas Steffen

Abstract readMulticenter StudyComparative Study
In one paragraph

Article in BJS open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kristjan UkegjiniDepartment of Surgery, HOCH Health Ostschweiz, St Gallen, Switzerland.ORCID 0000-0002-3127-8852
José OberholzerDepartment of Surgery and Transplantation, Swiss Hepatopancreatobiliary and Transplant Center Zurich, University Hospital Zurich, Zürich, Switzerland.
Philip C MüllerDepartment of Surgery, Clarunis-University Centre for Gastrointestinal and Hepatopancreatobiliary Diseases, Basel, Switzerland.ORCID 0000-0001-8317-3449
Rene WarschkowDepartment of Surgery, HOCH Health Ostschweiz, St Gallen, Switzerland.
Ignazio TarantinoDepartment of Surgery, HOCH Health Ostschweiz, St Gallen, Switzerland.
Jan Philipp JonasDepartment of Surgery and Transplantation, Swiss Hepatopancreatobiliary and Transplant Center Zurich, University Hospital Zurich, Zürich, Switzerland.
Marie KleinDepartment of Surgery, HOCH Health Ostschweiz, St Gallen, Switzerland.
Henrik PetrowskyDepartment of Surgery and Transplantation, Swiss Hepatopancreatobiliary and Transplant Center Zurich, University Hospital Zurich, Zürich, Switzerland.
Bruno M SchmiedDepartment of Surgery, HOCH Health Ostschweiz, St Gallen, Switzerland.
Thomas SteffenDepartment of Surgery, HOCH Health Ostschweiz, St Gallen, Switzerland.ORCID 0000-0001-9374-5703

Funding

The Cancer League of Eastern Switzerland
6 · The paper itself

Abstract

backgroundThis study aimed to compare the accuracy of the Comprehensive Complication Index (CCI) with that of the Clavien-Dindo classification in patients undergoing pancreatoduodenectomy.

methodsA two-centre, retrospective study was undertaken that included patients who underwent pancreatoduodenectomy between 2008 and 2022. Three approaches were used to assess the two complication scores: the Spearman rank test, yielding the correlation coefficient (r), the area under the curve with 95% confidence intervals, and a mixed-effects model and a generalized mixed-effects model that yielded odds ratios and β-coefficients.

resultsA total of 596 patients were included. The CCI and Clavien-Dindo classification demonstrated no correlation with 90-day mortality (r = - 0.021, 0.618; and r = -0.003, P = 0.951) but a significant correlation with length of hospital stay (r = 0.620, P < 0.001; and r = 0.605, P < 0.001) and with 90-day readmission rate (r = 0.148, P < 0.001; and r = 0.120, P = 0.005). The accuracy of the CCI was superior to that of the Clavien-Dindo classification for length of hospital stay dichotomized at the 75th (P = 0.022) and 90th (P < 0.001) percentiles. The CCI significantly improved the effect of the Clavien-Dindo classification (random effect, P < 0.001) in the mixed-effects and generalized mixed-effects logistic regression analyses.

conclusionCompared with the Clavien-Dindo classification, the CCI appeared to be more accurate in terms of its association with a prolonged hospital stay and 90-day readmission rate. The CCI should complement the Clavien-Dindo classification in clinical and research settings.

Indexed as

PancreaticoduodenectomyPostoperative ComplicationsAgedAged, 80 and overFemaleHumansLength of StayMaleMiddle AgedPatient ReadmissionRetrospective Studies

Identifiers

PMID41564010
PMCPMC12822778

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.