Evidence map›Paper›PMID 41563701›Full record

ArticleClinical journal of gastroenterology2026

Eosinophilic cholangitis without peripheral eosinophilia presenting as a localized bile duct stricture mimicking perihilar cholangiocarcinoma.

Takeshi Mori, Yasutaka Ishii, Shinya Nakamura, Juri Ikemoto, Masaru Furukawa, Yumiko Yamashita, Koji Arihiro, Kenichiro Uemura, Shinya Takahashi, Shiro Oka

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Article in Clinical journal of gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Takeshi MoriDepartment of Gastroenterology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Yasutaka IshiiDepartment of Gastroenterology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan. yishii@hiroshima-u.ac.jp.ORCID http://orcid.org/0000-0003-3545-8743
Shinya NakamuraDepartment of Gastroenterology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Juri IkemotoDepartment of Gastroenterology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Masaru FurukawaDepartment of Gastroenterology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Yumiko YamashitaDepartment of Gastroenterology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Koji ArihiroDepartment of Anatomical Pathology, Hiroshima University Hospital, Hiroshima, Japan.
Kenichiro UemuraDepartment of Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Shinya TakahashiDepartment of Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Shiro OkaDepartment of Gastroenterology, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Eosinophilic cholangitis is a rare condition characterized by the infiltration of the bile duct wall by inflammatory cells, predominantly eosinophils, leading to bile duct wall thickening, narrowing, and dilatation. Differentiation between primary sclerosing cholangitis and cholangiocarcinoma remains challenging owing to overlapping clinical and radiological features, and no standardized diagnostic criteria currently exist. We report a case of eosinophilic cholangitis presenting as a localized biliary stricture in a 65 year-old man. The patient underwent computed tomography for the evaluation of worsening diabetes, which incidentally revealed a stricture at the hepatic hilum. Magnetic resonance cholangiopancreatography and endoscopic retrograde cholangiopancreatography (ERCP) demonstrated a hilar biliary stricture with left intrahepatic bile duct dilatation. Bile cytology was interpreted as atypical, brush cytology was negative for malignancy, and bile duct biopsy showed no evidence of malignancy. Transoral cholangioscopy also revealed no malignant features; however, follow-up ERCP showed progression of the right-sided biliary stricture. As hilar cholangiocarcinoma could not be ruled out, the patient opted for surgical intervention. A left hepatectomy with caudate lobectomy was performed. Histopathological examination revealed no malignancy but showed submucosal fibrosis and inflammatory cell infiltration. Notably, marked eosinophilic infiltration was observed at the site of the right biliary stricture. The final diagnosis of the patient was eosinophilic cholangitis.

Indexed as

Bile Duct NeoplasmsCholangitisEosinophiliaKlatskin TumorAgedCholangiopancreatography, Endoscopic RetrogradeCholangiopancreatography, Magnetic ResonanceConstriction, PathologicDiagnosis, DifferentialHumansMaleBiopsyEndoscopic retrograde cholangiopancreatographyEosinophilic cholangitisIntraductal ultrasonographyPeroral cholangioscopy

Identifiers

PMID41563701

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.