Evidence map›Paper›PMID 41563683›Full record

ArticleBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]2026

Polyhexamethylene guanidine hydrochloride as active ingredient for anticariogenic products: studies in vitro and in vivo.

Fernanda Gosuen Gonçalves Dias, Francielle Aparecida de Sousa, Rodrigo Cássio Sola Veneziani, Renato Luis Tame Parreira, Lucas de Freitas Pereira, Denise Crispim Tavares, Saulo Duarte Ozelin, Tábata Rodrigues Esperandim, Maria Anita Lemos Vasconcelos Ambrósio, Victória Marques Russo Ramos and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Fernanda Gosuen Gonçalves DiasUniversity of Franca (UNIFRAN), Av. Dr. Armando Salles Oliveira, 201, Parque Universitário, Franca, SP, CEP: 14404-600, Brazil. fernanda.dias@unifran.edu.br.ORCID http://orcid.org/0000-0001-6072-4789
Francielle Aparecida de SousaCentro Universitário do Cerrado Patrocínio (UNICERP), Av. Líria Terezinha Lassi Capuano, 466, Afrânio Amaral, Patrocínio, MG, CEP: 38740-000, Brazil.
Rodrigo Cássio Sola VenezianiUniversity of Franca (UNIFRAN), Av. Dr. Armando Salles Oliveira, 201, Parque Universitário, Franca, SP, CEP: 14404-600, Brazil.
Renato Luis Tame ParreiraUniversity of Franca (UNIFRAN), Av. Dr. Armando Salles Oliveira, 201, Parque Universitário, Franca, SP, CEP: 14404-600, Brazil.
Lucas de Freitas PereiraUniversity of Franca (UNIFRAN), Av. Dr. Armando Salles Oliveira, 201, Parque Universitário, Franca, SP, CEP: 14404-600, Brazil.
Denise Crispim TavaresUniversity of Franca (UNIFRAN), Av. Dr. Armando Salles Oliveira, 201, Parque Universitário, Franca, SP, CEP: 14404-600, Brazil.
Saulo Duarte OzelinUniversity of Franca (UNIFRAN), Av. Dr. Armando Salles Oliveira, 201, Parque Universitário, Franca, SP, CEP: 14404-600, Brazil.
Tábata Rodrigues EsperandimUniversity of Franca (UNIFRAN), Av. Dr. Armando Salles Oliveira, 201, Parque Universitário, Franca, SP, CEP: 14404-600, Brazil.
Maria Anita Lemos Vasconcelos AmbrósioUniversity of Franca (UNIFRAN), Av. Dr. Armando Salles Oliveira, 201, Parque Universitário, Franca, SP, CEP: 14404-600, Brazil.
Victória Marques Russo RamosUniversity of Franca (UNIFRAN), Av. Dr. Armando Salles Oliveira, 201, Parque Universitário, Franca, SP, CEP: 14404-600, Brazil.
Jhenice Palmeira GallinaUniversity of Franca (UNIFRAN), Av. Dr. Armando Salles Oliveira, 201, Parque Universitário, Franca, SP, CEP: 14404-600, Brazil.
Isabela Rodrigues CaetanoUniversity of Franca (UNIFRAN), Av. Dr. Armando Salles Oliveira, 201, Parque Universitário, Franca, SP, CEP: 14404-600, Brazil.
Sérgio Ricardo AmbrósioUniversity of Franca (UNIFRAN), Av. Dr. Armando Salles Oliveira, 201, Parque Universitário, Franca, SP, CEP: 14404-600, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dental caries is a highly prevalent multifactorial oral disease that can cause both local and systemic lesions. The aim of this study was to evaluate the in vitro antiseptic effect of a topical solution containing polyhexamethylene guanidine hydrochloride (PHMGH) and its possible toxic effects in vivo. PHMGH was tested (0.31-625.0 ppm) against Streptococcus mutans, Streptococcus sanguinis, Streptococcus salivarius, Streptococcus mitis, Streptococcus sobrinus, Lactobacillus casei, and Enterococcus faecalis by determining the minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), minimum biofilm inhibitory concentration (MBIC

Indexed as

Anti-Infective Agents, LocalDental CariesGuanidinesStreptococcusAnimalsBiofilmsMaleMicrobial Sensitivity TestsRatsRats, WistarAnti-Infective Agents, LocalGuanidinespolyhexamethyleneguanidineClinical safetyDental cariesDentistryMouthwashOral diseaseSynthetic polymer

Identifiers

PMID41563683
PMCPMC12824067

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.