Observational studyEsophagus : official journal of the Japan Esophageal Society2026
Prolonged surgical time and hypoalbuminemia as risk factors for adverse outcomes after esophagectomy: a multicenter study with age-stratified and spline-based analysis.
Observational study in Esophagus : official journal of the Japan Esophageal Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEsophagectomy is associated with high morbidity. Prolonged surgical time, low body mass index, and hypoalbuminemia have been implicated as potential risk factors. However, their age-specific and nonlinear associations with postoperative outcomes remain unclear.
methodsThis multicenter retrospective study included 338 patients who underwent elective esophagectomy for histologically confirmed esophageal cancer between 2018 and 2024. The primary outcome was a composite of severe complications within 30 days, including mortality, reoperation, renal replacement therapy, or mechanical ventilation. Multivariable logistic regression was used to evaluate risk factors, with age-stratified analysis (< 70 vs. ≥ 70 years) and restricted cubic spline modeling applied to assess nonlinear associations.
resultsThe primary outcome occurred in 15.4% of patients. In the overall cohort, prolonged surgical time (OR 1.061 per 10 min, p < 0.001) and hypoalbuminemia (OR 0.312, p = 0.002) were independent predictors. Among patients < 70 years, operative time, hypoalbuminemia, and male sex were significant risk factors. Among those ≥ 70 years, operative time and low body mass index were associated with increased risk. Spline analysis revealed a continuous increase in the risk of complications with longer surgeries. A significant interaction was observed between body mass index and age (p = 0.024).
conclusionsProlonged surgical time and hypoalbuminemia are independent predictors of adverse outcomes after esophagectomy. The impact of body mass index varies by age, with low body mass index posing a greater risk in older patients. These findings highlight the need for individualized perioperative assessment based on age and physiological status.
Indexed as
Identifiers
41563681What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.