Evidence map›Paper›PMID 41563670›Full record

ArticleMolecular diversity2026

Design and synthesis of novel thiazole/1,2,4-triazole/quinoline hybrids as antiproliferative agents, apoptosis inducers, immunomodulators, and multi-EGFR/BRAF

Aliaa M Mohassab, Bahaa G M Youssif, Abdullah Yahya Abdullah Alzahrani, Hesham A Abou-Zied, Stefan Bräse, Mohamed A A Abdel-Aal, Kamal S Abdelrahman, Samar H Abbas

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Article in Molecular diversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Aliaa M Mohassab *Medicinal Chemistry Department, Faculty of Pharmacy, Minia University, 61519, Minia, Egypt.
Bahaa G M Youssif *Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, 71526, Assiut, Egypt. bgyoussif2@gmail.com.
Abdullah Yahya Abdullah AlzahraniDepartment of Chemistry, Faculty of Science, King Khalid University, 61413, Abha, Saudi Arabia.
Hesham A Abou-ZiedMedicinal Chemistry Department, Faculty of Pharmacy, Deraya University, Minia, Egypt.
Stefan BräseInstitute of Biological and Chemical Systems, IBCS-FMS, Karlsruhe Institute of Technology, 76131, Karlsruhe, Germany. braese@kit.edu.
Mohamed A A Abdel-AalDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, 71524, Assiut, Egypt.
Kamal S AbdelrahmanDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, 71524, Assiut, Egypt.
Samar H AbbasMedicinal Chemistry Department, Faculty of Pharmacy, Minia University, 61519, Minia, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We developed a novel category of quinoline-based compounds that operate as multi-target inhibitors of EGFR, HER-2, and BRAF

Indexed as

Antineoplastic AgentsApoptosisDrug DesignErb-b2 Receptor Tyrosine KinasesProtein Kinase InhibitorsProto-Oncogene Proteins B-rafQuinolinesThiazolesTriazolesCell Line, TumorCell ProliferationErbB ReceptorsHumansMolecular Docking SimulationMolecular Dynamics SimulationStructure-Activity RelationshipAntineoplastic AgentsBRAF protein, humanEGFR protein, humanErb-b2 Receptor Tyrosine KinasesErbB ReceptorsProtein Kinase InhibitorsProto-Oncogene Proteins B-rafquinolineQuinolinesThiazolesTriazoles1,2,4-TriazoleAntiproliferativeKinase inhibitorsQuinolineThiazole

Identifiers

PMID41563670
PMCPMC13332894

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.