Evidence map›Paper›PMID 41563669›Full record

ArticleMolecular diversity2026

Synthesis of redox-responsive polyurethane nanocapsules for small-molecule delivery and antitumor evaluation on human leukemia K562 cells.

Na Shi, Mengting Liu, Dandan He, Nianlin Feng, Yi Zhang, Dandan Liu, Chenchen Li, Zhenchao Wang

Abstract read
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In one paragraph

Article in Molecular diversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Na Shi *Guizhou Engineering Laboratory for Synthetic Drugs, College of Pharmacy, Guizhou University, Guiyang, 550025, People's Republic of China.
Mengting Liu *Guizhou Engineering Laboratory for Synthetic Drugs, College of Pharmacy, Guizhou University, Guiyang, 550025, People's Republic of China.
Dandan HeGuizhou Engineering Laboratory for Synthetic Drugs, College of Pharmacy, Guizhou University, Guiyang, 550025, People's Republic of China.
Nianlin FengGuizhou Engineering Laboratory for Synthetic Drugs, College of Pharmacy, Guizhou University, Guiyang, 550025, People's Republic of China.
Yi ZhangGuizhou Engineering Laboratory for Synthetic Drugs, College of Pharmacy, Guizhou University, Guiyang, 550025, People's Republic of China.
Dandan LiuGuizhou Engineering Laboratory for Synthetic Drugs, College of Pharmacy, Guizhou University, Guiyang, 550025, People's Republic of China.
Chenchen LiGuizhou Engineering Laboratory for Synthetic Drugs, College of Pharmacy, Guizhou University, Guiyang, 550025, People's Republic of China. licc@gzu.edu.cn.
Zhenchao WangGuizhou Engineering Laboratory for Synthetic Drugs, College of Pharmacy, Guizhou University, Guiyang, 550025, People's Republic of China. zcwang@gzu.edu.cn.

Funding

Guizhou Provincial Basic Research Program (Natural Science) Youth Guidance Project QN[2025]010Guizhou Provincial Foundation for Excellent Scholars Program GCC[2023]072National Key R&D Program of China 2023YFD1400400National Natural Science Foundation of China 32360689
6 · The paper itself

Abstract

High concentrations of glutathione (GSH) in the tumor microenvironment (TME) represent a promising target for the development of polyurethane (PU)-based redox-responsive drug delivery systems. A series of 3-indolopyrazole acetamide derivatives were designed and synthesized in this study. The anti-proliferative activities of these compounds were evaluated in tumor cell lines, and the small molecule S11 (IC

Indexed as

Antineoplastic AgentsDrug CarriersDrug Delivery SystemsNanocapsulesPolyurethanesApoptosisCell ProliferationDrug LiberationGlutathioneHumansK562 CellsMembrane Potential, MitochondrialOxidation-ReductionReactive Oxygen SpeciesAntineoplastic AgentsDrug CarriersGlutathioneNanocapsulesPolyurethanesReactive Oxygen SpeciesAnti-tumorDrug delivery systemK562Polyurethane

Identifiers

PMID41563669

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.