Evidence map›Paper›PMID 41563659›Full record

ReviewDiscover oncology2026

Current situation and research progress of luteolin in the treatment of gastrointestinal malignant tumors.

Zeyu Tu, Tianlu Chu, Peipei Yang, Hengchao Guan, Xinyan Shu, Yinghong Li, Yuhao Teng, Yuanyuan Xu, Peng Shu

Abstract readReview
In one paragraph

Review in Discover oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zeyu TuAffiliated Hospital of Nanjing University of Chinese Medicine, No.155, Hanzhong Road, Nanjing, Jiangsu, 210029, China.
Tianlu ChuAffiliated Hospital of Nanjing University of Chinese Medicine, No.155, Hanzhong Road, Nanjing, Jiangsu, 210029, China.
Peipei YangAffiliated Hospital of Nanjing University of Chinese Medicine, No.155, Hanzhong Road, Nanjing, Jiangsu, 210029, China.
Hengchao GuanAffiliated Hospital of Nanjing University of Chinese Medicine, No.155, Hanzhong Road, Nanjing, Jiangsu, 210029, China.
Xinyan ShuAffiliated Hospital of Nanjing University of Chinese Medicine, No.155, Hanzhong Road, Nanjing, Jiangsu, 210029, China.
Yinghong LiAffiliated Hospital of Nanjing University of Chinese Medicine, No.155, Hanzhong Road, Nanjing, Jiangsu, 210029, China.
Yuhao TengAffiliated Hospital of Nanjing University of Chinese Medicine, No.155, Hanzhong Road, Nanjing, Jiangsu, 210029, China.
Yuanyuan XuAffiliated Hospital of Nanjing University of Chinese Medicine, No.155, Hanzhong Road, Nanjing, Jiangsu, 210029, China.
Peng ShuAffiliated Hospital of Nanjing University of Chinese Medicine, No.155, Hanzhong Road, Nanjing, Jiangsu, 210029, China. shupengnjucm@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Luteolin, known for its anti-inflammatory and antioxidant properties, has garnered attention for its potential anticancer effects. Research has shown that luteolin can modulate the proliferation, migration, invasion, drug resistance, and apoptosis of digestive tract cancer cells by targeting specific pathways. This review summarizes the current understanding of luteolin's impact on five types of digestive tract malignancies both in vitro and in vivo, elucidates its molecular mechanisms in regulating these cancers, and highlights the existing limitations and gaps in research. This analysis aims to inform the safety assessment, enhance the bioavailability, and guide the formulation development and clinical utilization of luteolin in the context of digestive tract malignancies.

Indexed as

Anticancer mechanismsChinese herbal medicineCombination therapyDigestive tract malignanciesFlavonoidsLuteolin

Identifiers

PMID41563659
PMCPMC12909643

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.