Evidence map›Paper›PMID 41563633›Full record

ArticleTranslational stroke research2026

Outcomes of Bypass Surgery in Patients with Moyamoya Syndrome Secondary To Sickle Cell Disease: a Multicenter Study.

Basel Musmar, Joanna M Roy, Hammam Abdalrazeq, Celine Yacoub, Nimer Adeeb, Antony A Fuleihan, Sravanthi Koduri, Michael Baldassari, Matthews Lan, Pious Patel and 47 more

Abstract readMulticenter Study
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In one paragraph

Article in Translational stroke research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

57 authors.

Basel MusmarDepartment of Neurological Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Joanna M RoyDepartment of Neurological Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Hammam AbdalrazeqDepartment of Neurosurgery, Louisiana State University Health Science Center, Shreveport, LA, USA.
Celine YacoubDepartment of Neuroscience, Florida State University, Miami, FL, USA.
Nimer AdeebDepartment of Neurosurgery, Louisiana State University Health Science Center, Shreveport, LA, USA.
Antony A FuleihanDepartment of Neurological Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Sravanthi KoduriDepartment of Neurological Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Michael BaldassariDepartment of Neurological Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Matthews LanDepartment of Neurological Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Pious PatelDepartment of Neurological Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Arbaz A MominDepartment of Neurological Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Elias AtallahDepartment of Neurological Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Rabab AlshahraniDepartment of Neurological Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Spyridon KaradimasDepartment of Neurological Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Saman SizdahkhaniDepartment of Neurological Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Ajay GargDepartment of Neurological Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Kareem El NaamaniDepartment of Neurosurgery, University of Arizona College of Medicine, Tucson, AZ, USA.
Ching-Jen ChenDepartment of Neurosurgery, CHI Health Creighton University Medical Center - Bergan Mercy, Omaha, NE, USA.
Roland JabreDepartment of Neurological Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Hassan SaadDepartment of Neurosurgery, Emory University, Atlanta, GA, USA.
Jonathan A GrossbergDepartment of Neurosurgery, Emory University, Atlanta, GA, USA.
Adam A DmytriwDepartment of Medical Imaging, University of Toronto Faculty of Medicine, Toronto, ON, Canada.
Aman B PatelNeuroendovascular Program, Massachusetts General Hospital & Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Mirhojjat KhorasanizadehNeurosurgical Service, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Christopher S OgilvyNeurosurgical Service, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Ajith J ThomasDepartment of Neurological Surgery, Cooper University Health Care, Cooper Medical School of Rowan University, Camden, NJ, USA.
Andre MonteiroDepartment of Neurosurgery, University of New York at Buffalo, Buffalo, NY, USA.
Adnan SiddiquiDepartment of Neurosurgery, University of New York at Buffalo, Buffalo, NY, USA.
Gustavo M CortezLyerly Neurosurgery, Baptist Health System, Jacksonville, Jacksonville, FL, USA.
Ricardo A HanelLyerly Neurosurgery, Baptist Health System, Jacksonville, Jacksonville, FL, USA.
Rahim Abo KasemDepartment of Neurosurgery and Neuroendovascular Surgery, Medical University of South Carolina, Charleston, SC, USA.
Guilherme PortoDepartment of Neurosurgery and Neuroendovascular Surgery, Medical University of South Carolina, Charleston, SC, USA.
Alejandro M SpiottaDepartment of Neurosurgery and Neuroendovascular Surgery, Medical University of South Carolina, Charleston, SC, USA.
Anthony J PiscopoDepartment of Neurosurgery, University of Iowa Hospital and Clinics, Iowa City, IA, USA.
David M HasanDepartment of Neurosurgery, Duke University, Durham, NC, USA.
Mohammad GhorbaniDepartment of Neurosurgery, Firoozgar Hospital, Tehran, Iran.
Joshua WeinbergDepartment of Neurosurgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Shahid M NimjeeDepartment of Neurosurgery, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Kimon BekelisGood Samaritan Hospital Medical Center, Babylon, NY, USA.
Mohamed M SalemDepartment of Neurosurgery, Hospital of the University of Pennsylvania, Penn Medicine, Philadelphia, PA, USA.
Jan-Karl BurkhardtDepartment of Neurosurgery, Hospital of the University of Pennsylvania, Penn Medicine, Philadelphia, PA, USA.
Akli ZetchiDepartment of Neurosurgery, Yale University, New Haven, CT, USA.
Charles MatoukDepartment of Neurosurgery, Yale University, New Haven, CT, USA.
Brian M HowardDepartment of Neurosurgery, Emory University, Atlanta, GA, USA.
Rosalind LaiDepartment of Neurosurgery, University of New York at Buffalo, Buffalo, NY, USA.
Rose DuNeuroendovascular Program, Massachusetts General Hospital & Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Rawad AbbasDepartment of Neurological Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Abdelaziz AmllayDepartment of Neurosurgery, Yale University, New Haven, CT, USA.
Alfredo MunozDepartment of Neurological Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Nabeel A HerialDepartment of Neurological Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Stavropoula I TjoumakarisDepartment of Neurological Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Michael Reid GoochDepartment of Neurological Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Christina NotarianniDepartment of Neurosurgery, Louisiana State University Health Science Center, Shreveport, LA, USA.
Bharat GuthikondaDepartment of Neurosurgery, Louisiana State University Health Science Center, Shreveport, LA, USA.
Jacques MorcosDepartment of Neurosurgery, UT Health Sciences Center at Houston, McGovern Medical School, Houston, TX, USA.
Robert H RosenwasserDepartment of Neurological Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Pascal JabbourDepartment of Neurological Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, USA. pascal.jabbour@jefferson.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMoyamoya syndrome (MMS) associated with sickle cell disease (SCD) is a severe vasculopathy that significantly increases stroke risk. While cerebral revascularization is increasingly considered in this population, concerns about perioperative safety and long-term outcomes have limited its use in clinical practice.

methodsWe conducted a multicenter, retrospective cohort study of 553 patients with MMS who underwent surgical revascularization across 13 centers. Patients were grouped by SCD status (SCD-MMS vs. moyamoya disease (MMD)). Primary outcomes included perioperative stroke, perioperative complications, and functional status at discharge. Secondary outcomes included length of stay, and follow-up stroke.

resultsOf 553 patients, 32 (5.8%) had SCD. There were no significant differences in overall perioperative stroke (OR 1.05, 95% CI 0.19 to 5.54), symptomatic perioperative stroke (OR 0.94, 95% CI 0.09 to 8.94), perioperative complications (OR 1.66, 95% CI 0.47 to 5.86), or follow-up stroke (OR 0.88, 95% CI 0.17 to 4.55). Functional outcomes at discharge were similarly favorable in both groups (mRS 0-1: OR 0.84, 95% CI 0.29 to 2.40). SCD was associated with a longer hospital stay (beta 2.78 days, 95% CI 0.60 to 4.96).

conclusionSurgical revascularization for MMS in patients with SCD does not confer additional procedural risk and yields outcomes comparable to those of patients without SCD. These findings support the role of bypass surgery as a viable treatment option in this high-risk population.

Indexed as

Anemia, Sickle CellCerebral RevascularizationMoyamoya DiseaseAdolescentAdultCohort StudiesFemaleHumansMaleMiddle AgedPostoperative ComplicationsRetrospective StudiesStrokeTreatment OutcomeYoung AdultBypass, moyamoyaCohortMulticenterRevascularizationSickle cell

Identifiers

PMID41563633

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