Evidence map›Paper›PMID 41563591›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2026

Real world outcomes of reperfusion treatments in acute ischemic stroke (AIS): a prospective cohort study.

Pinky Chhatterpal, Deepti Vibha, Rajesh Kumar Singh, Awadh Kishor Pandit, Animesh Das, Arunmozhimaran Elavarasi, Rohit Bhatia, Achal Kumar Srivastava, Manjari Tripathi, Leve Joseph and 2 more

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Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

Authors and funding

12 authors.

Pinky ChhatterpalDepartment of Neurology, All India Institute of Medical Sciences, New Delhi, India.
Deepti VibhaDepartment of Neurology, All India Institute of Medical Sciences, New Delhi, India. deeptivibha@gmail.com.ORCID http://orcid.org/0000-0003-3659-7526
Rajesh Kumar SinghDepartment of Neurology, All India Institute of Medical Sciences, New Delhi, India.
Awadh Kishor PanditDepartment of Neurology, All India Institute of Medical Sciences, New Delhi, India.
Animesh DasDepartment of Neurology, All India Institute of Medical Sciences, New Delhi, India.
Arunmozhimaran ElavarasiDepartment of Neurology, All India Institute of Medical Sciences, New Delhi, India.
Rohit BhatiaDepartment of Neurology, All India Institute of Medical Sciences, New Delhi, India.
Achal Kumar SrivastavaDepartment of Neurology, All India Institute of Medical Sciences, New Delhi, India.
Manjari TripathiDepartment of Neurology, All India Institute of Medical Sciences, New Delhi, India.
Leve JosephDepartment of Neuroimaging and Interventional Neuroradiology, All India Institute of Medical Sciences, New Delhi, India.
Ajay GargDepartment of Neuroimaging and Interventional Neuroradiology, All India Institute of Medical Sciences, New Delhi, India.
Shailesh B GaikwadDepartment of Neuroimaging and Interventional Neuroradiology, All India Institute of Medical Sciences, New Delhi, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionReperfusion Treatment(RT) options for Acute Ischemic Stroke(AIS) within 24 hours include: intravenous thrombolysis(IVT)(within 4.5 hours) and/or mechanical thrombectomy(MT). The utilization of benefits in 'real world' scenario, especially in Lower-Middle Income countries(LMICs) is not known. We aimed to determine the 'real-world' utilization and effectiveness of RT. PATIENTS AND

methodsIn a single-center prospective cohort study, we collected data of all AIS patients coming within 24 hours. Patients receiving RT(IVT/MT/both) and those who were ineligible and received medical management (MM) were compared for the clinical, radiological characteristics and outcomes at 90-days assessed by modified Rankin Scale (mRS). The secondary outcomes were poor outcome at 90 days(mRS 3-6), Barthel Index(BI), Caregiver Strain Index(CSI), Stroke Specific Quality of Life(SSQoL) and mortality.

resultsIn the study period (January 2022-September 2023), there were 302 patients. The mean age was 55.9(SD:15.7) years and majority were males (64.9%). Patients who underwent RT (42.7%(129/302)) had similar clinical characteristics, except for lesser time to presentation, better Glasgow Coma Scale(GCS), and better median ASPECTS. IVT was given to 33.4%(101/302) and MT in 14.6%(44/302). The mRS at 90-days was significantly better in the RT group (RT:1(0;3), MM:3(1;5);P <0.001). RT was an independent protective factor (OR: 0.3(0.2;0.4); p-value:<0.001) for worse outcome (mRS 3-6). Other factors associated with mRS 3-6 at 90-days in multivariate analysis were high NIHSS and low ASPECTS at presentation.

conclusionsRT is feasible and effective in LMICs. Since the burden of stroke is increasing in LMICs and mean age of stroke is lower, post-stroke disability prevention by RT is an important intervention.

Indexed as

Ischemic StrokeReperfusionThrombolytic TherapyAdultAgedCohort StudiesFemaleFibrinolytic AgentsHumansMaleMiddle AgedProspective StudiesTreatment OutcomeFibrinolytic AgentsAcute ischemic strokeIntravenous thrombolysisMechanical thrombectomyProspective cohort studyReal-worldReperfusion treatment

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PMID41563591

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.