Evidence map›Paper›PMID 41563550›Full record

ArticleFunctional & integrative genomics2026

Dynamic epigenetic and transcriptomic reprogramming during embryonic skin development in goose (Anser anser domesticus).

Yuxuan Zhou, Xinyue Li, Jingbo Wang, Ichraf Mabrouk, Qiuyuan Liu, Yupu Song, Hongxiao Pan, Jingyun Ma, Xinwen Zhang, Jingtao Hu and 1 more

Abstract read
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In one paragraph

Article in Functional & integrative genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yuxuan Zhou *College of Animal Science and Technology, Jilin Agricultural University, Changchun, China.
Xinyue Li *College of Animal Science and Technology, Jilin Agricultural University, Changchun, China.
Jingbo Wang *College of Animal Science and Technology, Jilin Agricultural University, Changchun, China.
Ichraf MabroukCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, China.
Qiuyuan LiuCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, China.
Yupu SongCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, China.
Hongxiao PanCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, China.
Jingyun MaCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, China.
Xinwen ZhangCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, China.
Jingtao HuCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, China.
Yongfeng SunCollege of Animal Science and Technology, Jilin Agricultural University, Changchun, China. sunyongfeng@jlau.edu.cn.

Funding

National Natural Science Foundation of China 32372872Talent Special Support Program of Science and Technology Department of Jilin Province 20240601058RC
6 · The paper itself

Abstract

Feather follicles are specialized skin appendages that are essential for thermoregulation, protection, and down production in birds, forming through complex genetic and epigenetic interactions during embryogenesis. In this study, we examined skin and follicle development in Hungarian white goose embryos, focusing on dynamic epigenetic-transcriptomic changes. Histology showed smooth epidermis at E10, feather buds at E13, and columnar follicles with medullary tissue and secondary follicles at E18. Transcriptomics revealed 1327 and 1847 DEGs enriched in epidermal development, differentiation, and adhesion. Primordial initiation at E10-E13 featured Wnt, TGF-β, and melanogenesis, whereas follicle formation at E13-E18 involved lipid metabolism and VEGF signaling. Keratinization genes were continuously upregulated, and Wnt, Shh, and muscle pathways were activated late. Key regulators included LEF1, MSX2, and FOXN1. ATAC-seq showed dynamic chromatin accessibility, stage-specific promoter openness, and motifs for YY1, KLF5, and KLF4. Differentially accessible regions enriched genes in Wnt and TGF-β signaling, cell adhesion, and mitophagy, shifting from proliferation and basic metabolism at E10-E13 to differentiation, lipid metabolism, and homeostasis at E13-E18. Integrated analyses linked fatty acid metabolism, MAPK, and FoxO signaling to differentiation, while downregulation of redox and migration pathways preserved homeostasis. Some fatty acid metabolism and cell polarity genes increased expression despite reduced accessibility at E13-E18, indicating epigenetic pre-programming and post-transcriptional interplay. This work delineates coordinated epigenetic-transcriptional regulation of goose embryonic skin and feather follicle morphogenesis, offering insights for avian and vertebrate skin appendage studies.

Indexed as

Embryonic DevelopmentEpigenesis, GeneticGeeseSkinTranscriptomeAnimalsFeathersGene Expression Regulation, DevelopmentalMelanogenesisATAC-seqEpigeneticsGooseRNA-seqSkin development

Identifiers

PMID41563550

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.