Evidence map›Paper›PMID 41563499›Full record

ArticleDie Naturwissenschaften2026

Wound healing potential of methanolic extract of Wrightia tinctoria fresh leaf.

Subramanian Subalakshmi, Dhanaventhan Simyaa, Subramanian Sruthivani, Veeraiyan Sweatha, Vellingiri Vadivel

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In one paragraph

Article in Die Naturwissenschaften, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Subramanian SubalakshmiChemical Biology Lab (ASK-II-409), School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, Tamilnadu, India.
Dhanaventhan SimyaaChemical Biology Lab (ASK-II-409), School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, Tamilnadu, India.
Subramanian SruthivaniChemical Biology Lab (ASK-II-409), School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, Tamilnadu, India.
Veeraiyan SweathaChemical Biology Lab (ASK-II-409), School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, Tamilnadu, India.
Vellingiri VadivelChemical Biology Lab (ASK-II-409), School of Chemical and Biotechnology, SASTRA Deemed University, Thanjavur, Tamilnadu, India. vadivel@carism.sastra.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fresh leaves of Wrightia tinctoria plant is used by traditional healers in India for wound healing. Even though few research studies conducted on the wound healing property of dry leaves, no scientific proof available for fresh leaf extract of W. tinctoria. The present work aims to analyse the phytochemical components in the fresh leaves of W. tinctoria and also to investigate the wound healing potential in excision wound model. The methanolic extract of fresh leaves possess high levels of phytochemical compounds and the GC-MS analysis indicated the presence of major phytochemicals 8-prenylnaringenin, bilobalide and trans-cinnamic acid. Methanolic extract recorded superior antioxidant, anti-inflammatory and antibacterial activities than other solvent extracts and also protected from intracellular generation of ROS in PBMC cells. Further, it induced angiogenesis in CAM model and found to be safe based on MTT assay. In vivo studies revealed that ointment prepared from methanolic extract of W. tinctoria fresh leaf healed the wound faster (100%) than betadine-treated on 13th day. Hence, methanolic extract of fresh leaves of W. tinctoria could be explored as potential candidate for the development of green and safe wound healing drug.

Indexed as

ApocynaceaePlant ExtractsPlant LeavesWound HealingAnimalsAnti-Bacterial AgentsAnti-Inflammatory AgentsAntioxidantsHumansMethanolAnti-Bacterial AgentsAnti-Inflammatory AgentsAntioxidantsMethanolPlant ExtractsAntioxidant, anti-inflammatory, anti-microbialFresh leavesPhytochemicalsWound healingWrightia tinctoria

Identifiers

PMID41563499

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.