ArticleNaunyn-Schmiedeberg's archives of pharmacology2026
Clarifying the mechanism of Curcumin in the treatment of neuropathic pain based on network pharmacology and molecular docking technology.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Curcumin induces ferroptosis in ovarian cancer cells through the Nrf2/GPX4 regulation axis.American journal of cancer research · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aims to identify the primary targets of Curcumin in neuropathic pain and clarify the underlying mechanisms involved. Network pharmacology and bioinformatics are used to explore the potential targets and biological functions of Curcumin in the treatment of neuropathic pain. The model of chronic neuropathic pain was established by ligation of the unilateral sciatic nerve to investigate the effect of Curcumin on neuropathic pain in rats. Paw withdrawal threshold (PWT) and paw withdrawal latency (PWL) measured by thermal stimulation were tested. H&E and TUNEL were used to detect tissue injury and apoptosis, respectively. Apoptosis-related proteins (caspase3, caspase9, cleaved-caspase3, cleaved-caspase9, Bax, Bcl-2) were detected by western blot. ELISA was used to detect the levels of inflammatory factors (IL-6, IL-10, TNF-α, and IL-1β) and oxidative stress indicators (ROS, SOD, and GSH-PX) in blood samples. The expression of core genes and proteins obtained from network pharmacology analysis was detected using RT-PCR and western blot, respectively. A total of 56 Curcumin-related targets were obtained. After intervention with Curcumin, the neuropathic pain symptoms can be significantly alleviated. The tissue damage and apoptosis were significantly inhibited. Curcumin could regulate the levels of inflammatory factors (IL-6, IL-10, TNF-α, and IL-1β) and oxidative stress indicators (ROS, SOD, and GSH-PX). The expressions of core genes and proteins (CCL-5, CXCR2, (P-)JAK2, (P-)STAT3, SRC, (P-)PI3K, (P-)AKT, HIF-1α, and NF-κB) were also adjusted by Curcumin. Curcumin exhibited biological functions of anti-apoptosis, anti-inflammation, and anti-oxidant stress against neuropathic pain. Curcumin can serve as a potential natural product for the treatment of neuropathic pain in the clinical setting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.