ArticleDermatologie (Heidelberg, Germany)2026
[IgA-positive anti-p200 pemphigoid mimicking erythema multiforme].
Article in Dermatologie (Heidelberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Anti-p200 pemphigoid is a rare subepidermal blistering dermatosis with variable clinical manifestations that can mimic other bullous skin diseases. We report the case of a 65-year-old patient presenting with extensive bullae on the palms and soles, as well as mucosal erosions. These findings were initially consistent with a diagnosis of erythema multiforme. Direct immunofluorescence (DIF) revealed linear IgA, IgG, and C3 antibody deposits along the dermoepidermal junction. While indirect immunofluorescence (IIF) on salt split skin demonstrated IgA and IgG antibodies binding on the dermal side of the split, immunoblot analysis revealed the presence of antibodies against the 200-kDa protein p200 as well as against laminin-β4. Based on these findings, the diagnosis of IgA-positive anti-p200 pemphigoid, a very rare variant barely described in literature, was made. This case highlights the importance of thorough differential diagnosis in blistering diseases and emphasizes the diagnostic value of immunohistochemical techniques.
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