Evidence map›Paper›PMID 41563418›Full record

Observational studyPediatric nephrology (Berlin, Germany)2026

Kidney and blood pressure sequelae after pediatric extracorporeal membrane oxygenation: a secondary analysis of the Kidney Injury During Membrane Oxygenation pediatric ECMO cohort.

Stephanie Reynaud, Jennifer G Jetton, Rashmi D Sahay, David T Selewski, David J Askenazi, Heidi J Steflik, Brian C Bridges, David S Cooper, Matthew L Paden, Rajit K Basu and 3 more

Abstract readMulticenter StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Pediatric nephrology (Berlin, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Stephanie ReynaudDepartment of Pediatric Critical Care IWK Health, Dalhousie University, Critical Care Department, Halifax, NS, Canada. stephanie.reynaud@iwk.nshealth.ca.ORCID http://orcid.org/0000-0003-1934-9280
Jennifer G JettonDepartment of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, USA.
Rashmi D SahayDivision of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
David T SelewskiDepartment of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
David J AskenaziDepartment of Pediatrics, University of Alabama Birmingham, Birmingham, AL, USA.
Heidi J SteflikDepartment of Pediatrics, Medical University of South Carolina, Charleston, SC, USA.
Brian C BridgesDepartment of Pediatrics, Medical University of South Carolina, Charleston, SC, USA.
David S CooperDepartment of Pediatrics, University of Cincinnati College of Medicine, The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Matthew L PadenChildren's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA, USA.
Rajit K BasuDivision of Critical Care Medicine, The Ann & Robert Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Stephen M GorgaDepartment of Pediatrics, University of Michigan Medical School, Ann Arbor, MI, USA.
Eileen KingDivision of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Katja M GistDepartment of Pediatrics, University of Colorado Anschutz Medical Campus, School of Medicine, Children's Hospital Colorado, Aurora, CO, USA.

Funding

Gerber Foundation 7/1/2022-6/30-2025
6 · The paper itself

Abstract

backgroundAcute kidney injury (AKI) is common in children treated with extracorporeal membrane oxygenation (ECMO) and is associated with increased morbidity and mortality. AKI may also increase the risk of long-term chronic kidney disease (CKD) and persistent kidney dysfunction. Hospital discharge kidney dysfunction (HDKD) or the need for antihypertensive medication may further be associated with long-term CKD risk. This study aims to determine, in children treated with ECMO, the prevalence of HDKD and the use of antihypertensive medication at hospital discharge, as well as their associations with AKI during ECMO.

methodsRetrospective cohort study, including 6 pediatric centers. Children on ECMO between 2007-2011 ("KIDMO" cohort) surviving hospital discharge.

results354 children included, median age 25 days ([IQR] 2-457); ECMO mode: 61.2% veno-arterial (VA), 38.8% veno-venous (VV); ECMO indication: pulmonary (62.1%), cardiac (20.9%), extracorporeal cardiopulmonary resuscitation (ECPR) (17%). AKI occurred in 66.1%; 53.4% had ≥ Stage 2 AKI, including kidney support therapy (KST) and 35% received KST. 12.1% had HDKD and 33.2% were treated with anti-hypertensive medication at discharge. In patients with HDKD or treatment with anti-hypertensive medication, AKI was more frequent (HDKD: p < 0.0001; anti-hypertensive medication: p < 0.0001). In multivariable analysis, AKI and pediatric (vs. neonatal) age were associated with HDKD; cardiac or ECPR indication for ECMO and older age were associated with the need for anti-hypertensive medication at discharge.

conclusionsHDKD and anti-hypertensive medication at hospital discharge are common in pediatric ECMO survivors and associated with AKI. AKI is a known risk for long-term CKD and hypertension; systematic kidney health follow-up should be considered in these children.

Indexed as

Acute Kidney InjuryExtracorporeal Membrane OxygenationHypertensionRenal Insufficiency, ChronicAntihypertensive AgentsBlood PressureChildChild, PreschoolFemaleHumansInfantInfant, NewbornMalePrevalenceRetrospective StudiesRisk FactorsAntihypertensive AgentsChildrenChronic kidney injuryExtracorporeal membrane oxygenationHypertensionOutcome

Identifiers

PMID41563418

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.