Evidence map›Paper›PMID 41563389›Full record

ArticleJournal of the American Society of Nephrology : JASN2026

Severe Maternal Morbidity and Long-Term Kidney Outcomes among Pregnant Women Receiving Maintenance Dialysis.

Lauren M Kucirka, Kim A Boggess, Mollie E Wood, Johanna Quist-Nelson, Vimal K Derebail, Jennifer E Flythe, Andrea Chalem, Tracy A Manuck, Michelle L Meyer, Alison M Stuebe and 1 more

Abstract read
In one paragraph

Article in Journal of the American Society of Nephrology : JASN, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lauren M KucirkaDivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.ORCID 0009-0001-0617-4015
Kim A BoggessDivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.
Mollie E WoodDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.ORCID 0000-0002-9302-2641
Johanna Quist-NelsonDivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.ORCID 0000-0003-3390-5239
Vimal K DerebailDivision of Nephrology and Hypertension, Department of Medicine, UNC Kidney Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.ORCID 0000-0002-7662-7497
Jennifer E FlytheDivision of Nephrology and Hypertension, Department of Medicine, UNC Kidney Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.ORCID 0000-0003-4596-8536
Andrea ChalemDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.ORCID 0000-0002-2959-0070
Tracy A ManuckDivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.ORCID 0000-0002-2465-6747
Michelle L MeyerDepartment of Emergency Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.ORCID 0000-0001-7085-3154
Alison M StuebeDivision of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.ORCID 0000-0002-1228-4587
Monica L ReynoldsDivision of Nephrology and Hypertension, Department of Medicine, UNC Kidney Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina.ORCID 0000-0002-9988-8833

Funding

The Pharmacoepigenomics of Recurrent Preterm Birth in Non-Hispanic Black WomenR01MD011609 · NIMHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MANUCK, TRACY A. · 2017 to 2021
$3.8M
Patient-oriented research and mentoring in preterm birth toxicogenomicsK24ES031131 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI TRACY A. MANUCK · 2020 to 2026
$1.0M
NIEHS NIH HHS K24 ES031131NIEHS NIH HHS K24-ES031131NIH HHS R01-MD011609NIMHD NIH HHS R01 MD011609
6 · The paper itself

Abstract

key pointsIn the United States, one in three pregnant women receiving maintenance dialysis experienced severe maternal morbidity from 2000 to 2020. History of severe maternal morbidity was associated with higher mortality and a longer time to kidney transplantation in the years following delivery.

backgroundPregnant women receiving maintenance dialysis are at high risk for adverse pregnancy outcomes. Little is known about their rates of severe maternal morbidity and the association of severe maternal morbidity with future kidney transplant wait times and mortality.

methodsThis is a cohort study of women who gave birth while receiving maintenance dialysis from January 1, 2000, to December 31, 2019, as captured in the United States Renal Data System. Nonkidney severe maternal morbidity, defined by the US Centers for Disease Control and Prevention, was assessed from 4 weeks before birth to 6 weeks postpartum. Multivariable regression models examined risk factors independently associated with severe maternal morbidity. Multivariable Cox proportional hazards were stratified by the presence or absence of severe maternal morbidity to examine time to mortality, and, separately, the receipt of a kidney transplant.

resultsWe identified 1082 births among 986 women who were receiving dialysis at the time of birth. In total, 332 women (34%) and 342 births (32%) experienced at least one nonkidney severe maternal morbidity. The most common severe maternal morbidity events were blood transfusion (16% of all births), pulmonary edema/acute heart failure (10%), sepsis (6%), and acute respiratory distress syndrome (5%). In multivariable analyses, risk factors independently associated with severe maternal morbidity included Black or other/unknown race, body mass index >35 kg/m 2 , and dialysis initiation within 1 year before giving birth. Patients who experienced severe maternal morbidity had a higher risk of mortality than those who did not (adjusted hazard ratio, 1.69; 95% confidence interval, 1.30 to 2.19) and were less likely to receive a kidney transplant than those who did not (adjusted subhazard ratio, 0.76; 95% confidence interval, 0.59 to 0.97).

conclusionsIn the United States, one in three pregnant women receiving maintenance dialysis experienced severe maternal morbidity with risk factors that included recent dialysis initiation. In the following years, the history of severe maternal morbidity was associated with higher mortality and a longer time to kidney transplantation.

Indexed as

Kidney Failure, ChronicPregnancy ComplicationsRenal DialysisAdultCohort StudiesFemaleHumansKidney TransplantationPregnancyPregnancy OutcomeRisk FactorsSeverity of Illness IndexTime FactorsUnited Stateswomen's health

Identifiers

PMID41563389
PMCPMC13143437

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.