ArticleMolecular biology of the cell2026
Early lipid-mediated responses to hyperosmotic stress at the yeast vacuole.
Article in Molecular biology of the cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
In yeast, early adaptation to hyperosmotic stress involves organelle-based mechanisms, including synthesis of phosphatidylinositol 3,5-bisphosphate (PI(3,5)P₂) in the endolysosomal system. This low-level signaling lipid drives vacuolar fragmentation and activates the V-ATPase, which acidifies the vacuole and promotes salt sequestration. Under NaCl stress, PI(3,5)P₂ rapidly accumulates, triggering increased V-ATPase activity and vacuolar remodeling; these responses are impaired by deficient PI(3,5)P₂ synthesis. We visualized movements of a GFP fusion protein with the cytosolic domain of V-ATPase subunit Vph1 (Vph1NT-GFP) in a microfluidic system during salt stress. Upon NaCl addition, Vph1NT-GFP rapidly relocalizes to a region adjacent to the vacuole in a PI(3,5)P
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