Evidence map›Paper›PMID 41563251›Full record

ReviewInfection and immunity2026

Antibodies in tuberculosis: functional capacity as key determinant.

Krista E van Meijgaarden, Patricia S Grace, Natalia T Freund, Jacqueline M Achkar, Thomas Lindenstrøm, Joshua Tan, John Chan, Carolyn G King, Tom H M Ottenhoff, Simone A Joosten and 1 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Infection and immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. HowVaccines · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Krista E van MeijgaardenLeiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0003-2818-9805
Patricia S GraceDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Natalia T FreundDepartment of Clinical Microbiology and Immunology, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
Jacqueline M AchkarDepartment of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.
Thomas LindenstrømDepartment of Infectious Disease Immunology, Center for Vaccine Research, Statens Serum Institut, Copenhagen, Denmark.
Joshua TanAntibody Biology Unit, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Rockville, Maryland, USA.
John ChanDepartment of Medicine, Center for Emerging Pathogens, Public Health Research Institute, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA.
Carolyn G KingDepartment of Biomedicine, Infection Immunology Laboratory, University of Basel, Basel, Switzerland.
Tom H M OttenhoffLeiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0003-3706-3403
Simone A JoostenLeiden University Center for Infectious Diseases (LUCID), Leiden University Medical Center, Leiden, The Netherlands.
CTVD B cell group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The human immune system employs both innate and adaptive mechanisms to control pathogens, with antibodies playing a pivotal role in immune memory and defense, in particular against viral infections. In tuberculosis, antibody titers have long been used to assess immune responses, but their presence alone fails to predict protective efficacy. Recent studies highlight that antibody functionality is critical for effective immune activity. Despite widespread detection of

Indexed as

Antibodies, BacterialMycobacterium tuberculosisTuberculosisAnimalsHumansAntibodies, Bacterialantibodiesfunctional assaystuberculosis

Identifiers

PMID41563251
PMCPMC12890035

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.