Evidence map›Paper›PMID 41563169›Full record

ArticleJournal of the American College of Cardiology2026

Impact of Early, Delayed, or Interrupted Treatment in Children With Familial Hypercholesterolemia.

Yun-Lin Huang, Sarah D de Ferranti, Jacob Hartz, Yiyi Zhang, Natalia Ruiz-Negrón, Dhruv S Kazi, Amit V Khera, Jessica G Woo, Elaine M Urbina, David R Jacobs and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American College of Cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yun-Lin HuangMailman School of Public Health, Columbia University Irving Medical Center, New York, New York, USA.
Sarah D de FerrantiDepartment of Pediatrics, Harvard Medical School, Boston, Massachusetts, USA.
Jacob HartzLevine Children's Hospital, Charlotte, North Carolina, USA.
Yiyi ZhangDivision of General Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Natalia Ruiz-NegrónNDB Consulting Services, LLC, Saint Cloud, Florida, USA.
Dhruv S KaziRichard A. and Susan F. Smith Center for Outcomes Research in Cardiology, Division of Cardiovascular Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Amit V KheraDepartment of Medicine, Harvard Medical School, Boston, Massachusetts, USA; Division of Cardiology, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA; Verve Therapeutics, Boston, Massachusetts, USA.
Jessica G WooDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA; Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
Elaine M UrbinaDepartment of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA; The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
David R JacobsDivision of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota, USA.
Norrina B AllenDepartment of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
John B WongDivision of Clinical Decision Making, Department of Medicine Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA.
Andrew E MoranDivision of General Medicine, Columbia University Irving Medical Center, New York, New York, USA.
Brandon K BellowsDivision of General Medicine, Columbia University Irving Medical Center, New York, New York, USA. Electronic address: bkb2132@cumc.columbia.edu.

Funding

Childhood CV Risk and Adult CVD Outcomes: an International Long-term Follow-upR01HL121230 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI BURNS, TRUDY L, CHEN, WEI · 2015 to 2019
$13.3M
Familial hypercholesterolemia screening in children: population impact of phenotype, genotype, and cascade approachesR01HL141823 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI DE FERRANTI, SARAH D, MORAN, ANDREW EDWARD · 2019 to 2022
$3.3M
Improving Lipid Management Strategies in Young AdultsR01HL168379 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Jaejin An, Yiyi Zhang · 2023 to 2026
$2.9M
NHLBI NIH HHS R01 HL121230NHLBI NIH HHS R01 HL141823NHLBI NIH HHS R01 HL168379
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

cholesterolfamilial hypercholesterolemialipid-lowering treatment

Identifiers

PMID41563169
PMCPMC13334911

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.