Evidence map›Paper›PMID 41563144›Full record

ArticleJournal of natural products2026

Discovery of Suomilide and Cyanopeptolin Analogues by

Isabel M Chauvin, Lydia J Davis, Aleksej Krunic, Jimmy Orjala

Abstract read
In one paragraph

Article in Journal of natural products, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Isabel M ChauvinDepartment of Pharmaceutical Sciences, University of Illinois Chicago, Chicago, Illinois 60612, United States.ORCID 0000-0002-6537-2097
Lydia J DavisDepartment of Pharmaceutical Sciences, University of Illinois Chicago, Chicago, Illinois 60612, United States.ORCID 0000-0002-0898-7191
Aleksej KrunicDepartment of Pharmaceutical Sciences, University of Illinois Chicago, Chicago, Illinois 60612, United States.
Jimmy OrjalaDepartment of Pharmaceutical Sciences, University of Illinois Chicago, Chicago, Illinois 60612, United States.ORCID 0000-0002-4420-2048

Funding

Project 3:Isolation Chemistry of Filamentous Fungi and Biological EvaluationP01CA125066 · NCI · OHIO STATE UNIVERSITY · PI JIMMY ORJALA · 2007 to 2026
$27.2M
NMR User Program at NMRFAMR24GM141526 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Katherine Anne Henzler-Wildman · 2021 to 2026
$6.4M
Research Training in Natural Product Complementary and Integrative HealthT32AT007533 · NCCIH · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Joanna E Burdette, JIMMY ORJALA · 2013 to 2026
$4.3M
STRUCTURAL BIOL RES: LUNG SURFACTANT PROTEINS, DISTRESSS10RR019071 · NCRR · NORTHWESTERN UNIVERSITY · PI RADHAKRISHNAN, ISHWAR · 2005 to 2005
$272k
NCCIH NIH HHS T32 AT007533NCI NIH HHS P01 CA125066NCRR NIH HHS S10 RR019071NIGMS NIH HHS R24 GM141526
6 · The paper itself

Abstract

Cyanobacteria have been a promising source for natural product drug discovery for decades using mainly activity-guided approaches. More recently, genome mining and bioinformatics-guided approaches have become increasingly utilized in bacterial drug discovery and have proven to be successful in revealing novel metabolites predicted by biosynthetic gene clusters. However, detection and identification of these predicted metabolites can be difficult. Connecting nitrogen-containing natural products with the corresponding gene clusters encoding them in cyanobacteria can be aided by cyanobacteria's ability to incorporate inorganic nitrogen into their secondary metabolites. Feeding cyanobacteria with

Indexed as

CyanobacteriaNostocPeptides, CyclicBiological ProductsIsotope LabelingMolecular StructureMultigene FamilyNitrogen IsotopesNuclear Magnetic Resonance, BiomolecularBiological ProductsNitrogen IsotopesPeptides, Cyclic

Identifiers

PMID41563144
PMCPMC12860550

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.