Evidence map›Paper›PMID 41562852›Full record

ArticleProteomes2026

Beyond Repression: ArsR Functions as a Global Activator of Metabolic and Redox Responses in

Brett Sather, James Larson, Kian Hutt Vater, Jade Westrum, Timothy R McDermott, Brian Bothner

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proteomes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Genomic Features of the MicropredatorInternational journal of molecular sciences · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Brett SatherDepartment of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59717, USA.ORCID 0009-0009-2608-228X
James LarsonDepartment of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59717, USA.ORCID 0000-0001-9920-7682
Kian Hutt VaterDepartment of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59717, USA.
Jade WestrumDepartment of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59717, USA.
Timothy R McDermottDepartment of Land Resources and Environmental Science, Montana State University, Bozeman, MT 59717, USA.
Brian BothnerDepartment of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59717, USA.ORCID 0000-0003-1295-9609

Funding

Division of Chemical Sciences, Geosciences, and Biosciences, Office of Basic Energy Sciences of the U.S. Department of Energy DE-SC0020246IDeA National Resource for Quantitative Proteomics at University of Arkansas School for Medical Science through their National Institute of General Medical Sciences R24GM137786
6 · The paper itself

Abstract

backgroundThe arsenic-responsive repressor, ArsR, has long been understood as a canonical regulator of the

methodsUsing mass-spectrometry-based shotgun proteomics and statistical analyses, we characterized the differential abundance of proteins across AW3110 (Δ

resultsOur study shows that ArsR influences proteomic networks beyond the

conclusionsThese findings challenge the classical view of ArsR as a repressor and position it as a pleiotropic regulator, including broad activation.

Indexed as

arsenic stress responseArs operon expressionArsR regulationdifferential proteome analysisEscherichia coli proteomemass spectrometry-based proteomic analysisproteome stress responseproteomic pathway analysis

Identifiers

PMID41562852
PMCPMC12821715

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.