Evidence map›Paper›PMID 41562620›Full record

ReviewJournal of virology2026

AP2: an indispensable host factor in virus infection.

Rui Li, Yan Jiang, Xinrong Wang, Longxiang Zhang, Yue Wang

Abstract readReview
In one paragraph

Review in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rui LiCollege of Veterinary Medicine, Southwest University, Chongqing, China.
Yan JiangCollege of Veterinary Medicine, Southwest University, Chongqing, China.
Xinrong WangCollege of Veterinary Medicine, Southwest University, Chongqing, China.
Longxiang ZhangCollege of Veterinary Medicine, Southwest University, Chongqing, China.ORCID 0009-0005-9612-7931
Yue WangCollege of Veterinary Medicine, Southwest University, Chongqing, China.ORCID 0000-0003-1575-3569

Funding

Fundamental Research Funds for the Central Universities SWU-KQ22035National Natural Science Foundation of China 32302852National Natural Science Foundation of China 32573404Natural Science Foundation of Chongqing CSTB2023NSCQ-MSX0366Science and Technology Research Program of Chongqing Municipal Education Commission KJQN202300224
6 · The paper itself

Abstract

Adaptor protein complex 2 (AP2), a central regulator of clathrin-mediated endocytosis and intracellular cargo trafficking, is hijacked by numerous viruses to complete their infectious cycles. This review systematically synthesizes the multifaceted roles of AP2 across the entire viral life cycle, from entry and replication to assembly and release, as well as in immune evasion. By delineating how diverse viruses exploit this key host machinery, we further consolidate the rationale and current progress in developing broad-spectrum antiviral strategies that target AP2 and its regulatory pathways. This work aims to provide a unified perspective on AP2 as a critical host-pathogen interface, offering new insights into viral pathogenesis and antiviral drug discovery.

Indexed as

Adaptor Protein Complex 2Host-Pathogen InteractionsVirus DiseasesAnimalsAntiviral AgentsGenome, ViralHumansImmune EvasionProtein Processing, Post-TranslationalProtein SubunitsVirus InternalizationVirus ReplicationAdaptor Protein Complex 2Antiviral AgentsProtein Subunitsadaptor protein complex 2antiviral drug targetsimmune evasionvirus cellular transportvirus life cycle

Identifiers

PMID41562620
PMCPMC12911872

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.