Evidence map›Paper›PMID 41562471›Full record

Trial reportSkin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)2026

A Randomized Controlled Trial of the Genistein Plus Bakuchiol and Vitamins (GEN

Mingkwan Na Takuathung, Kantirat Yaja, Jakkrit Aisara, Preeyaporn Klinjan, Pannita Anek, Ratchanon Inpan, Tattiya Kantasa, Jeeraporn Chitphan, Kankanit Yeerong, Supanimit Teekachunhatean and 1 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. A Randomized Controlled Trial of the Genistein Plus Bakuchiol and Vitamins (GENSkin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2026
    Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mingkwan Na TakuathungDepartment of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.ORCID https://orcid.org/0000-0003-4240-5367
Kantirat YajaDepartment of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Jakkrit AisaraDepartment of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Preeyaporn KlinjanDepartment of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Pannita AnekDepartment of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Ratchanon InpanDepartment of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Tattiya KantasaDepartment of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.ORCID https://orcid.org/0009-0008-2377-0194
Jeeraporn ChitphanDepartment of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Kankanit YeerongDepartment of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Supanimit TeekachunhateanDepartment of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.ORCID https://orcid.org/0000-0003-1329-379X
Nut KoonrungsesomboonDepartment of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.ORCID https://orcid.org/0000-0003-4649-597X

Funding

CMU Mid-Career Research Fellowship program MRCMU2566R_009CMU Mid-Career Research Fellowship program MRCMU2567-2_008
6 · The paper itself

Abstract

backgroundWith increasing life expectancy, the aging population, particularly in Asia, is expanding rapidly. Combined with intense year-round ultraviolet exposure, this accelerates skin aging. Male skin also exhibits distinct aging characteristics. This study aims to evaluate the efficacy and safety of the Genistein Plus Bakuchiol and Vitamins (GEN MATERIALS AND

methodsA randomized, double-blind, placebo-controlled trial was conducted in men aged 45-65 years. Participants were assigned to receive either the GEN

resultsEighty male participants were enrolled (GEN

conclusionThe GEN

trial registrationClinicalTrials.gov identifier: TCTR20240312001.

Indexed as

GenisteinSkin AgingVitaminsAgedDouble-Blind MethodDrug CombinationsFaceHumansMaleMiddle AgedPhenolsSkinSkin PigmentationTreatment OutcomebakuchiolDrug CombinationsGenisteinPhenolsVitaminsbakuchiolclaim substantiationgenisteinmale skincaresafety testingskin physiology/structure

Identifiers

PMID41562471
PMCPMC12821225

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.