Evidence map›Paper›PMID 41562316›Full record

ReviewJournal of integrative plant biology2026

Linking cellular metabolism to chromatin modifications in plants.

Jaewoong Hwang, Pil Joon Seo

Abstract readReview
In one paragraph

Review in Journal of integrative plant biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Linking cellular metabolism to chromatin modifications in plants.Journal of integrative plant biology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jaewoong HwangDepartment of Chemistry, Seoul National University, Seoul, 08826, South Korea.ORCID https://orcid.org/0009-0009-3354-9909
Pil Joon SeoDepartment of Chemistry, Seoul National University, Seoul, 08826, South Korea.ORCID https://orcid.org/0000-0002-5499-3138

Funding

National Research Foundation of Korea RS-2025-00517108
6 · The paper itself

Abstract

Beyond their traditional roles as biological building blocks and energy sources, metabolites also influence gene expression, exerting direct effects on the epigenetic landscape. For example, core metabolites such as acetyl coenzyme A (acetyl-CoA) and S-adenosylmethionine (SAM) serve as substrates or cofactors for chromatin-modifying enzymes, thereby modulating transcription through the chemical modification of histones and DNA. In addition, metabolites regulate the transcription of the genes encoding these chromatin modifiers, as well as the post-translational modifications and enzymatic activities of these proteins. Therefore, we propose that the metabolic state of a cell or organism is a dynamic and active driver of epigenomic reprogramming, adjusting gene expression in response to fluctuations in the environment.

Indexed as

ChromatinPlantsEpigenesis, GeneticHistonesProtein Processing, Post-TranslationalChromatinHistonesallosteric controlchromatin modifierDNA methylationenzyme substrateepigeneticshistone PTMsmetabolism

Identifiers

PMID41562316
PMCPMC13446589

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.