Evidence map›Paper›PMID 41562261›Full record

ReviewCell transplantation

Research progress and application prospect of engineered small extracellular vesicles.

Haoyu Zhang, Jian Chen, Xijie Tang, Xiangzhong Liu, Zhanghua Li

Abstract readReview
In one paragraph

Review in Cell transplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Haoyu ZhangWuhan Sports University, Wuhan, People's Republic of China.ORCID 0009-0000-4439-4492
Jian ChenWuhan Sports University, Wuhan, People's Republic of China.
Xijie TangDepartment of Orthopedics, Wuhan Third Hospital, Tongren Hospital of Wuhan University, Wuhan, People's Republic of China.
Xiangzhong LiuDepartment of Orthopedics, Wuhan Third Hospital, Tongren Hospital of Wuhan University, Wuhan, People's Republic of China.ORCID 0000-0002-9664-9167
Zhanghua LiDepartment of Orthopedics, Wuhan Third Hospital, Tongren Hospital of Wuhan University, Wuhan, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular vesicles (Evs) act as a natural intercellular message transmitter, Evs can carry proteins, ribonucleic acid (RNA) and other bioactive substances, and have rich biological regulatory functions. Because of its low immunogenicity and high biocompatibility, it has become a popular research object in drug delivery. These remarkable properties also create new opportunities for modern therapy. However, due to the complex preparation process, there are challenges in terms of targeting accuracy, load release controllability, and pharmacokinetic optimization, and many problems may be encountered in reality. Based on real-life biomedical experiments, this paper summarizes the methods and types of Evs loading drugs, membrane modification methods, and the use of biological materials to improve the release efficiency, so as to provide reference for future research on engineered Evs.

Indexed as

Drug Delivery SystemsExtracellular VesiclesAnimalsHumansdrug deliveryEv engineeringEvsEv therapyexosome

Identifiers

PMID41562261
PMCPMC12827922

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.