Evidence map›Paper›PMID 41562096›Full record

ArticleFrontiers in immunology2025

TGFβ1 attenuates microglial IL1β release through inhibition of NLRP3 inflammasome priming.

Christopher Kalischer, Phani Sankar Potru, Nele Lehmann, Jannik Jahn, Nikolai Leander Rupp, Natascha Vidovic, Tamara Russ, Susanne Wiemann, Björn Spittau

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Christopher Kalischer *Institute of Anatomy, University of Rostock, Rostock, Germany.
Phani Sankar Potru *Bielefeld University, Medical School OWL, Anatomy and Cell Biology, Bielefeld, Germany.
Nele LehmannBielefeld University, Medical School OWL, Anatomy and Cell Biology, Bielefeld, Germany.
Jannik JahnInstitute of Anatomy, University of Rostock, Rostock, Germany.
Nikolai Leander RuppBielefeld University, Medical School OWL, Anatomy and Cell Biology, Bielefeld, Germany.
Natascha VidovicBielefeld University, Medical School OWL, Anatomy and Cell Biology, Bielefeld, Germany.
Tamara RussBielefeld University, Medical School OWL, Anatomy and Cell Biology, Bielefeld, Germany.
Susanne WiemannBielefeld University, Medical School OWL, Anatomy and Cell Biology, Bielefeld, Germany.
Björn SpittauInstitute of Anatomy, University of Rostock, Rostock, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Microglia reactivity has been described as a driver of brain tissue damage in multiple neurodegenerative pathologies. One of the key features of reactive microglia is the transcriptional upregulation of in ammatory markers, including components of the NLRP3 inflammasome such as Methods: Using BV2 cells, primary microglia, qPCR, and western blotting the effect of TGFβ1 on LPS-induced inflammasome priming and activation was addressed. Results: In the present study, we demonstrate that TGFβ1 is able to abrogate LPS-induced transcriptional upregulation of the inflammasome-associated genes Discussion: Together, our data enhance the understanding of how TGFβ1 and microglial TGFβ signaling regulate microglial reactivity, further highlighting the essential functions of TGFβ1 as a potentimmunoregulatory factor for microglia.

Indexed as

InflammasomesInterleukin-1betaMicrogliaNLR Family, Pyrin Domain-Containing 3 ProteinTransforming Growth Factor beta1AnimalsCaspase 1LipopolysaccharidesMiceMice, Inbred C57BLMice, KnockoutReceptor, Transforming Growth Factor-beta Type IISignal TransductionCaspase 1IL1B protein, mouseInflammasomesInterleukin-1betaLipopolysaccharidesNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseReceptor, Transforming Growth Factor-beta Type IITgfb1 protein, mouseTransforming Growth Factor beta1IL1binflammasomeLPSmicrogliaNLRP3TGFβ1

Identifiers

PMID41562096
PMCPMC12813031

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.