Evidence map›Paper›PMID 41562092›Full record

ArticleFrontiers in immunology2025

Site- and structure-specific characterization of glycoproteins of H11: potent vaccine candidates against parasitic worm

Xin Liu, Feng Liu, Hui Liu, Lisha Ye, Yao Zhang, Wenjie Peng, Nishith Gupta, Min Hu, Chunqun Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

9 authors.

Xin LiuNational Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Feng LiuNational Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Hui LiuNational Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Lisha YeNational Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Yao ZhangNational Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Wenjie PengShanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China.
Nishith GuptaIntracellular Parasite Education and Research Labs (iPEARL), Department of Biological Sciences, Birla Institute of Technology and Science, Pilani (BITS Pilani), Hyderabad, India.
Min HuNational Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Chunqun WangNational Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parasitic worm (helminth) infections pose significant threats to global health and livestock productivity. Although mass spectrometry (MS)-based glycomics have revealed that helminths express structurally complex N-glycans, site- and structure-specific characterization of intact glycopeptides remains a major challenge. Here we employed advanced MS-based intact glycoproteomics to explore the N-glycosylation profile of H11 antigen - an important vaccine antigen derived from the pathogenic parasite

Indexed as

Antigens, HelminthGlycoproteinsHaemonchiasisHaemonchusHelminth ProteinsVaccinesAnimalsAntibodies, HelminthEpitopesGlycosylationImmunoglobulin GMiceMolecular Docking SimulationPolysaccharidesAntibodies, HelminthAntigens, HelminthEpitopesGlycoproteinsHelminth ProteinsImmunoglobulin GPolysaccharidesVaccinesglycan analysisintact N-glycopeptide analysisN-glycoproteomeparasitic wormvaccine

Identifiers

PMID41562092
PMCPMC12813067

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.