Evidence map›Paper›PMID 41562090›Full record

ArticleFrontiers in immunology2025

Genetic variants of the HLA-G/LILRB1 ligand-receptor axis in donors or recipients are prognostic covariates for rejection after living kidney transplantation.

Julian Hölzenbein, Sabine Schramm, Falko M Heinemann, Andreas Heinold, Anja Gäckler, Johanna Reinold, Benjamin Wilde, Yannik Busch, Nina Gruenen, Wolfgang Peter and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Julian HölzenbeinInstitute for Transfusion Medicine, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Sabine SchrammInstitute for Transfusion Medicine, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Falko M HeinemannInstitute for Transfusion Medicine, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Andreas HeinoldInstitute for Transfusion Medicine, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Anja GäcklerDepartment of Nephrology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Johanna ReinoldDepartment of Nephrology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Benjamin WildeDepartment of Nephrology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Yannik BuschInstitute for Transfusion Medicine, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Nina GruenenInstitute for Transfusion Medicine, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Wolfgang PeterHLA-Laboratory, Stefan-Morsch-Foundation, Birkenfeld, Germany.
Peter Alexander HornInstitute for Transfusion Medicine, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Oliver WitzkeDepartment of Infectious Diseases, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Hana Rohn *Department of Infectious Diseases, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Vera Rebmann *Institute for Transfusion Medicine, University Hospital Essen, University Duisburg-Essen, Essen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: HLA-G is a non-classical HLA class I molecule that promotes transplant tolerance. It engages the inhibitory receptor LILRB1 on immune effector cells, suppressing cytotoxic responses and inflammation, while promoting tolerogenic and regulatory immune phenotypes. Polymorphisms in the Methods: Living donor-recipient pairs undergoing KTx were genotyped for nine variants in the Results: Donor positivity for Conclusions: Donor

Indexed as

Graft RejectionHLA-G AntigensKidney TransplantationLeukocyte Immunoglobulin-like Receptor B1Living DonorsReceptors, Immunologic3' Untranslated RegionsAdultAntigens, CDFemaleGenotypeHaplotypesHumansMaleMiddle AgedPolymorphism, Single Nucleotide3' Untranslated RegionsAntigens, CDHLA-G AntigensLeukocyte Immunoglobulin-like Receptor B1LILRB1 protein, humanReceptors, Immunologicacute cellular rejectionHLA-G 3´UTR-1HLA-G 3´UTR-2humoral rejectionILT-2kidney transplantationLILRB1

Identifiers

PMID41562090
PMCPMC12812672

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.