Evidence map›Paper›PMID 41562044›Full record

ArticleEnvironment & health (Washington, D.C.)2026

Influence of Air Pollution Exposure on the microRNA Content of Neuronal Extracellular Vesicles in Subjects Affected by Major Depressive Disorder.

Paola Monti, Elisa Borroni, Rachele Matsagani, Eva Dariol, Laura Dioni, Davide Biganzoli, Simona Iodice, Guido Nosari, Francesca Legnani, Valentina Bollati and 3 more

Abstract read
In one paragraph

Article in Environment & health (Washington, D.C.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Paola MontiDepartment of Clinical Sciences and Community Health-Dipartimento di Eccellenza 2023-2027, University of Milan, Via San Barnaba 8, Milan 20122, Italy.ORCID https://orcid.org/0000-0001-8185-497X
Elisa BorroniDepartment of Clinical Sciences and Community Health-Dipartimento di Eccellenza 2023-2027, University of Milan, Via San Barnaba 8, Milan 20122, Italy.
Rachele MatsaganiDepartment of Clinical Sciences and Community Health-Dipartimento di Eccellenza 2023-2027, University of Milan, Via San Barnaba 8, Milan 20122, Italy.
Eva DariolDepartment of Clinical Sciences and Community Health-Dipartimento di Eccellenza 2023-2027, University of Milan, Via San Barnaba 8, Milan 20122, Italy.ORCID https://orcid.org/0009-0002-5675-3389
Laura DioniDepartment of Clinical Sciences and Community Health-Dipartimento di Eccellenza 2023-2027, University of Milan, Via San Barnaba 8, Milan 20122, Italy.
Davide BiganzoliDepartment of Clinical Sciences and Community Health-Dipartimento di Eccellenza 2023-2027, University of Milan, Via San Barnaba 8, Milan 20122, Italy.
Simona IodiceDepartment of Clinical Sciences and Community Health-Dipartimento di Eccellenza 2023-2027, University of Milan, Via San Barnaba 8, Milan 20122, Italy.
Guido NosariDepartment of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, Milan 20122, Italy.
Francesca LegnaniDepartment of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, Milan 20122, Italy.
Valentina BollatiDepartment of Clinical Sciences and Community Health-Dipartimento di Eccellenza 2023-2027, University of Milan, Via San Barnaba 8, Milan 20122, Italy.
Luca FerrariDepartment of Clinical Sciences and Community Health-Dipartimento di Eccellenza 2023-2027, University of Milan, Via San Barnaba 8, Milan 20122, Italy.
Massimiliano BuoliDepartment of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, Milan 20122, Italy.
Michele CarugnoDepartment of Clinical Sciences and Community Health-Dipartimento di Eccellenza 2023-2027, University of Milan, Via San Barnaba 8, Milan 20122, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Major depressive disorder (MDD) has been recently linked to air pollution exposure; nevertheless, the biological mechanisms underlying this association remain underinvestigated. Air pollution might modulate the microRNA (miRNA) content of neuron-derived extracellular vesicles (NdEVs), potentially mirroring brain epigenetic alterations. In the present study, we investigated the relationship between air pollution, NdEV miRNAs, and MDD severity in a population of 200 patients with depression. After signing informed consent, participants compiled questionnaires about demographics, lifestyle and clinical history, and donated a blood sample. MDD severity was assessed by five scales. Particulate matter ≤2.5 μm (PM

Indexed as

air pollutionmajor depressive disordermicroRNA (miRNA)neuron-derived extracellular vesiclesnitrogen dioxide (NO2)particulate matter (PM)

Identifiers

PMID41562044
PMCPMC12813701

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.