ArticleEnvironment & health (Washington, D.C.)2026
Developmental Mono(2-ethylhexyl) Phthalate Exposure Impairs Offspring Neurobehavior through Suppression of CYP450 Transcriptional Pathways.
Article in Environment & health (Washington, D.C.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phthalates, ubiquitous environmental contaminants, pose substantial risks to neurodevelopment, yet the mechanisms underlying their toxicity remain largely unknown. This study demonstrates that developmental exposure to mono-(2-ethylhexyl) phthalate (MEHP: 0, 10, and 50 mg/kg), the bioactive metabolite of di-(2-ethylhexyl) phthalate (DEHP), induced neurobehavioral deficits in adolescent offspring rats. Behavioral assessments revealed that the MEHP exposure provoked anxiety-like behaviors at postnatal days (PND) 14 and 21, concurrently manifested as spatial memory impairments at PND35. Histopathological analysis demonstrated significant neurodegenerative alterations in the hippocampus of MEHP-exposed offspring, including reduced Nissl body density in the 50 mg/kg group. Transcriptomic profiling identified a robust dose-dependent dysregulation pattern, with high-dose exposure (50 mg/kg) eliciting substantially more differentially expressed genes (542 DEGs) than low-dose exposure (393 DEGs). Analysis revealed suppression of cytochrome P450 (CYP450) pathways, characterized by the downregulation of
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