Evidence map›Paper›PMID 41561933›Full record

ArticleFrontiers in medicine2025

Effect of different modes of TPE on the prognosis of hypertriglyceridemic acute pancreatitis: a single-center retrospective study.

Ruiting Li, Yaqi Ouyang, Yaohui Ming, Ruishan Yao, Huiling Guo, Yanli Wu, Jin Zhou, Yaowen Yuan, Haiyan Huang, Yin Yuan and 1 more

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Article in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Ruiting Li *Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Yaqi Ouyang *Department of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Yaohui MingDepartment of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Ruishan YaoDepartment of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Huiling GuoDepartment of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Yanli WuDepartment of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Jin ZhouDepartment of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Yaowen YuanDepartment of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Haiyan HuangDepartment of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Yin YuanDepartment of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
You ShangDepartment of Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The management and treatment of hypertriglyceridemia-induced acute pancreatitis (HTG-AP) are similar to those of other causes of AP and include fluid resuscitation, nutritional support, and pain control. Along with supportive care, treatments for HTG specifically include therapeutic plasma exchange (TPE) to reduce the level of serum triglyceride (TG) which are crucial for the treatment and prognosis of HTG-AP patients. Aim: The purpose of this study was to evaluate the effects of different TPE modes [centrifugal TPE (cTPE) and membrane TPE (mTPE)] on the prognosis and clinical benefit of HTG-AP. Methods: This observational cohort study was conducted on 49 patients with HTG-AP who presented between January 2021 and December 2024. The patients were divided into the cTPE group and mTPE group based on the mode they received for TPE. Data were collected from patients included clinical characteristics, biochemical indices, therapeutic outcomes, and adverse events. Results: The results showed that TPE significantly reduced the levels of serum TG and total cholesterol (TC). Between the two TPE groups, the reduction of TC level in the cTPE group was more prominent. After the first TPE, the TG level decreased by 66.16% in the cTPE group Conclusion: This was the first study to compare the clinical benefits of cTPE and mTPE during the treatment of HTG-AP. cTPE showed a more significant advantage in improving coagulation function and pH, and the reduction of TC level in the cTPE group was more prominent. Additionally, the single cost of cTPE is lower. But there is insufficient evidence that cTPE is more beneficial for HTG-AP than mTPE, performing cTPE in combination with other therapies may be beneficial.

Indexed as

centrifugal plasma exchangehypertriglyceridemiahypertriglyceridemic acute pancreatitismembrane plasma exchangetherapeutic plasma exchange

Identifiers

PMID41561933
PMCPMC12813003

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.