ArticleMolecular and clinical oncology2026
Integrated multi-omics profiling of plasma extracellular vesicles reveals the hsa-miR-1-3p-LRP1 axis as a potential biomarker in cervical cancer.
Article in Molecular and clinical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cervical cancer (CC) is a malignancy characterized by persistent human papillomavirus (HPV) infection, immune evasion and tumor microenvironment remodeling. Due to its high invasiveness and drug resistance, effective diagnosis and treatment remain challenging. The present study employed multi-omics analysis to explore the molecular characteristics of plasma extracellular vesicles (EVs) in CC. EVs were isolated from the plasma of 3 patients with CC and 3 healthy controls via ultracentrifugation, and validated by nanoparticle tracking analysis, transmission electron microscopy and western blotting. MicroRNA (miRNA or miR) sequencing identified 22 differentially expressed miRNAs, the target genes of which were enriched in HPV infection, p53, PI3K-Akt and Wnt signaling pathways. Proteomic analysis revealed 49 differentially expressed proteins associated with complement activation, cholesterol metabolism and coagulation. Integrated analysis highlighted key miRNA-protein interaction networks, identifying hsa-miR-1-3p and LRP1 as potential diagnostic biomarkers, and their differential expression was further confirmed by reverse transcription-quantitative PCR. These findings provide novel insights into the role of EVs in CC pathogenesis and offer promising potential targets for early diagnosis and therapeutic intervention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.