ArticleFrontiers in aging neuroscience2025
Depressive symptoms mediate the relationship between cognitive reserve and cognitive performance in middle-aged and older Chinese adults: evidence from population-based and clinical PET cohorts including cognitively normal and cognitively impaired participants.
Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Abstract
Background: Cognitive reserve (CR) may protect cognitive performance under pathology. Depressive symptoms are common in mid and late life and are linked to poorer cognition. This study investigated whether depressive symptoms mediate the association between CR and both global and domain-specific cognitive performance in middle-aged and older Chinese adults. Methods: Data from 1,636 participants in the 2018 wave of the China Health and Retirement Longitudinal Study (the CHARLS 2018 cohort) were analyzed. Information from an independent retrospective cohort that underwent amyloid and tau positron emission tomography (PET) at Nanjing First Hospital (the PET cohort; Results: Across both cohorts, higher CR was associated with a lower risk of cognitive impairment and better domain-specific performance. Depressive symptoms partially mediated the association between CR and several domains of cognition in the analyses of the overall cohorts. In both the CHARLS 2018 subgroups, no mediation was detected. In the PET cohort, depressive symptoms fully mediated the effects of CR on executive function and attention in the MCI group, in which most participants showed tau deposition on PET, whereas no mediation was observed in the cognitively normal subgroup. Conclusion: CR is a protective factor for cognition, and depressive symptoms act as a modifiable mediator. In AD patients with confirmed tau pathology, timely detection and management of depressive symptoms may help preserve cognition and enhance the benefits of CR.
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