TAVI-in-TAVI in a patient with morquio syndrome: a case report.

Diana Xiao Lan Chin, Gianantonio De Michele, Davide Cristofani, Francesco De Felice

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Article in European heart journal. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

4 authors.

Diana Xiao Lan ChinDepartment of Cardiology, Interventional Cardiology Unit, San Camillo Hospital, Circ.ne Gianicolense 87, Rome 00152, Italy.ORCID https://orcid.org/0009-0003-1067-0358

Gianantonio De MicheleDepartment of Translational Medical Sciences; Division of Cardiology, University of Campania Luigi Vanvitelli, A.O.R.N. 'Sant'Anna & San Sebastiano', Caserta 81100, Italy.ORCID https://orcid.org/0009-0006-2500-4966

Davide CristofaniDepartment of Cardiology, Anesthesiology and Intensive Care Unit, San Camillo Hospital, Rome 00152, Italy.

Francesco De FeliceDepartment of Cardiology, Interventional Cardiology Unit, San Camillo Hospital, Circ.ne Gianicolense 87, Rome 00152, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Morquio syndrome (MPS IV) is a rare multi-systemic disorder with significant cardiovascular implications, including early-onset valvular disease. Due to the improved life expectancy, these patients could require complex interventional solutions such as TAVI-in-TAVI procedure. Case summary: We present the first reported case of a 65-year-old woman with Morquio syndrome undergoing a TAVI-in-TAVI procedure for structural degeneration of a prior transcatheter bioprosthetic valve. The procedure was technically challenging due to complex thoracic anatomy, small aortic annulus, and intermediate-risk of coronary obstruction. A self-expanding Evolut FX + valve were successfully implanted with favourable haemodynamic outcomes and no major complications. Conclusion: This case highlights the feasibility and importance of individualized planning in complex redo-TAVI interventions in patients with rare congenital disorders.

Indexed as

Aortic stenosisBioprosthetic valve failureCase reportMorquio SyndromeSelf-expanding transcatheter valveTAVI-in-TAVI

Identifiers

PMID41561774

DOI10.1093/ehjcr/ytaf662

PMCPMC12813499

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