Evidence map›Paper›PMID 41561742›Full record

ArticleFrontiers in oncology2025

Case Report: autologous stem cell boost enables hematopoietic recovery after severe cytopenia induced by BCMA-targeted bispecific antibody therapy in multiple myeloma.

Hiroaki Akiyama, Seiji Kakiuchi, Akimasa Sakamoto, Naru Tomigaki, Shutaro Fujioka, Isamu Harima, Ryotaro Niwa, Ikumi Takagi, Yoko Kozuki, Yoshiharu Miyata and 3 more

Abstract readCase Reports
In one paragraph

Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hiroaki Akiyama *Department of Hematology, Yodogawa Christian Hospital, Osaka, Japan.
Seiji Kakiuchi *Department of Hematology, Yodogawa Christian Hospital, Osaka, Japan.
Akimasa SakamotoDepartment of Hematology, Yodogawa Christian Hospital, Osaka, Japan.
Naru TomigakiDepartment of Hematology, Yodogawa Christian Hospital, Osaka, Japan.
Shutaro FujiokaDepartment of Hematology, Yodogawa Christian Hospital, Osaka, Japan.
Isamu HarimaDepartment of Hematology, Yodogawa Christian Hospital, Osaka, Japan.
Ryotaro NiwaDepartment of Hematology, Yodogawa Christian Hospital, Osaka, Japan.
Ikumi TakagiDepartment of Hematology, Yodogawa Christian Hospital, Osaka, Japan.
Yoko KozukiDepartment of Hematology, Yodogawa Christian Hospital, Osaka, Japan.
Yoshiharu MiyataDepartment of Artificial Intelligence and Digital Health Science, Kobe University Graduate School of Medicine, Kobe, Japan.
Kyoko YoshiharaDepartment of Hematology, Hyogo Medical University, Nishinomiya, Japan.
Satoshi YoshiharaDepartment of Hematology, Hyogo Medical University, Nishinomiya, Japan.
Nobuko IwataDepartment of Hematology, Yodogawa Christian Hospital, Osaka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Elranatamab, a bispecific antibody targeting B-cell maturation antigen (BCMA) and CD3, has shown significant efficacy in relapsed or refractory multiple myeloma (RRMM). However, elranatamab therapy also carries a risk of hematologic toxicity. Stem cell boost (SCB), involving reinfusion of previously collected autologous CD34

Indexed as

BCMAbispecific antibodycytopeniaelranatamabhematopoietic recoverymultiple myelomastem cell boost

Identifiers

PMID41561742
PMCPMC12812612

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.