ArticleFrontiers in oncology2025
Transcriptomics driven identification of hub gene miRNA interactions for biomarker and therapeutic target discovery in gynecological cancers.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: MicroRNAs (miRNAs) are small, single-stranded noncoding RNAs that play critical roles in disease development, including gynecological cancers like vulvar and cervical cancer. Their high heterogeneity makes achieving an accurate diagnosis difficult in modern clinical practice. Methods: In this study, we used Results: The statistical analysis of GEOR2 yielded 16,344 differentially expressed genes (DEGs), and through robust regression analysis, 229 common DEGs were retrieved. Among them, 94 and 135 genes were downregulated and upregulated, respectively. We retrieved ten hub genes via a protein-protein interaction network and cytohubba, namely CDK1, AURKA, BUB1B, CCNB1, TOP2A, KIF11, BUB1, CCNB2, CDCA8, and BIRC5. Following extensive Discussion: The identified miRNAs exhibit strong regulatory interactions with these hub genes, while serine/threonine protein kinases emerged as the most significantly associated group. Together, these findings highlight promising biomarker candidates and potential therapeutic targets for gynecological cancers.
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