ArticleFrontiers in neuroscience2025
Sylvian fissure angle development on fetal MRI: 22-38 gestational weeks.
Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: The objective of the study was to quantify Sylvian fissure angle (SFA) development via fetal magnetic resonance imaging (MRI) and establish the reference range and growth curve during normal pregnancy. Materials and methods: This retrospective cross-sectional study collected 324 singleton fetuses at 22-38 weeks of gestation (GA), without abnormal signs on MRI or chromosomal defects, from January 2022 to December 2023. Six SFAs were defined and measured: Sylvian fissure plateau angle (SFPA), Sylvian fissure anterior rotation angle (SFARA), and Sylvian fissure posterior rotation angle (SFPRA) in the transthalamic axial plane, and SFPA, Sylvian fissure superior rotation angle (SFSRA), and Sylvian fissure inferior rotation angle (SFIRA) in the third ventricular coronal plane. Then, the correlation between the SFAs and GA was analyzed, and the growth curve model was used. Retrospective cortical malformation cases validated the model. The intraclass correlation coefficient (ICC) was used to evaluate interobserver variability of the SFA measurements. Results: ICC for SFA measurements demonstrated good reliability (0.772-0.976). The bilateral SFARA and SFSRA were significantly positively associated with GA (r = 0.914, 0.926, 0.842, 0.836, left to right, all Conclusion: The dynamic development of the fetal SFA can be well evaluated using MRI. The SFA's reference range will enhance the accuracy of fetal brain assessment and offer a quantitative reference framework for identifying deviations suggestive of cortical malformations.
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