ArticleACS catalysis2026
Electronic and Steric Effects of the ProPhos Ligand Family for Nickel-Catalyzed Suzuki-Miyaura Coupling of Heteroaromatics.
Article in ACS catalysis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Access to and unexplored reactivity of nickel-bound 5-membered O- and N-heterocyclic arynesChemical science · 2026Article
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Authors and funding
6 authors.
Funding
Abstract
Nickel-catalyzed Suzuki-Miyaura coupling (Ni-SMC) reactions offer a cost-effective approach for active pharmaceutical ingredient (API) synthesis but remain constrained by their limited compatibility with heteroaromatic substrates and the need for high catalyst loadings. Our laboratory recently developed the ProPhos ligand, which significantly addresses these challenges. In this study, we systematically investigate the electronic and steric effects of the ProPhos ligand framework. Evaluation of over 20 ProPhos derivatives, alongside representative monodentate and bidentate phosphine ligands, reveals that the beneficial influence of the tethered hydroxyl group is general. Other nucleophilic substituents were less effective, and variations in the three-carbon linker length compromised the catalytic efficiency. Increased steric bulk on phosphorus decreased reactivity, whereas electron-donating substituents such as
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Registered trials
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