Evidence map›Paper›PMID 41561401›Full record

ArticleAmerican heart journal plus : cardiology research and practice2026

Coronary artery calcium score of zero does not rule out obstructive CAD in young adults.

O Smettei, R M Abazid, J G Romsa, C Akincioglu, J C Warrington, T B Alshaar, P J Teefy, S De, N Tzemos, R Zareardalan and 3 more

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In one paragraph

Article in American heart journal plus : cardiology research and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

O SmetteiDivision of Molecular Imaging and Theranostics, London Health Sciences Centre, London, Ontario, Canada.
R M AbazidDivision of Cardiology, Department of internal Medicine, Sault Area Hospital, Sault Ste Marie, Northern Ontario School of Medicine (NOSM) University, Ontario, P6B 0A8, Canada.
J G RomsaDivision of Molecular Imaging and Theranostics, London Health Sciences Centre, London, Ontario, Canada.
C AkinciogluDivision of Molecular Imaging and Theranostics, London Health Sciences Centre, London, Ontario, Canada.
J C WarringtonDivision of Molecular Imaging and Theranostics, London Health Sciences Centre, London, Ontario, Canada.
T B AlshaarDivision of Molecular Imaging and Theranostics, London Health Sciences Centre, London, Ontario, Canada.
P J TeefyDivision of cardiology, London Health Sciences Centre, London, Ontario, Canada.
S DeDivision of cardiology, London Health Sciences Centre, London, Ontario, Canada.
N TzemosDivision of cardiology, London Health Sciences Centre, London, Ontario, Canada.
R ZareardalanDivision of Molecular Imaging and Theranostics, London Health Sciences Centre, London, Ontario, Canada.
M BadreddineDigital Health Applications, London Health, Sciences Centre, London, Ontario, Canada.
Y BureauLawson Health Research Institute, Western University, Canada.
W C VezinaDivision of Molecular Imaging and Theranostics, London Health Sciences Centre, London, Ontario, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Young adults are more likely to have non-calcified coronary plaques. Purpose to assess the predictive value of a zero-coronary artery calcium (CAC) score in young adults and to determine which clinical characteristics are associated with obstructive coronary heart disease. Methods: 6775 patients were prospectively entered a registry. They all had a CAC. Mean age 63 +/- 18 years. 56.2 % males. 3525 patients underwent coronary CT angiography (CCTA). 3250 patients underwent single photon emission tomography (SPECT). SPECT patients were mainly outpatients. CCTA patients also were almost exclusively outpatients. Thus, the population was generally a low-risk population. Results: Among the CCTA patients, 1888 had a 0 CAC score. 175/1888 (9 %) had less than 70 % stenosis, while 41/1888 (2.2 %) had ≥70 % stenosis. Patients with ≥70 % stenosis: were younger 45 ± 12 yr versus 59 ± 11 yr, Conclusions: A zero CAC does not rule out significant CAD in young adults with chest pain with CAD risk factors. These patients may need further investigations.

Indexed as

Acute chest painAcute coronary syndromeCoronary calcium scoreCoronary computed tomography angiogramSPECT

Identifiers

PMID41561401
PMCPMC12814675

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.