Evidence map›Paper›PMID 41561377›Full record

ArticleiScience2026

The pivotal role of endoplasmic reticulum in cancer glucose metabolism.

Cecilia Marini, Maddalena Ghelardoni, Sonia Carta, Tiziana Bachetti, Silvia Bruno, Isotta Cainero, Silvia Ravera, Roberto Benelli, Marco Scotto, Francesca Vitale and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Cecilia MariniInstitute of Bioimaging and Complex Biological Systems, National Research Council (CNR), Milan, Italy.
Maddalena GhelardoniDepartment of Health Sciences, University of Genoa, Genoa, Italy.
Sonia CartaNuclear Medicine, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Tiziana BachettiProteomics and Mass Spectrometry Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Silvia BrunoDepartment of Experimental Medicine, Human Anatomy Section, University of Genoa, Genoa, Italy.
Isotta CaineroAdvanced Imaging Facility, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Silvia RaveraDepartment of Experimental Medicine, Human Anatomy Section, University of Genoa, Genoa, Italy.
Roberto BenelliMolecular Oncology and Angiogenesis Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Marco ScottoNanoscopy, CHT, Istituto Italiano di Tecnologia, Genoa, Italy.
Francesca VitaleNuclear Medicine, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Santina BruzzoneDepartment of Experimental Medicine, University of Genoa, Genoa, Italy.
Serena LosaccoDepartment of Health Sciences, University of Genoa, Genoa, Italy.
Sabrina ChiesaNuclear Medicine, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Matteo BaucknehtNuclear Medicine, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Gabriele TancredaDepartment of Health Sciences, University of Genoa, Genoa, Italy.
Matteo RaineriProteomics and Mass Spectrometry Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Anna Maria OrengoNuclear Medicine, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Andrea BenziDepartment of Experimental Medicine, University of Genoa, Genoa, Italy.
Gianmario SambucetiNuclear Medicine, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The endoplasmic reticulum (ER) supports essential biosynthetic and quality control functions. These processes rely on sustained energy supply and precise redox control within the ER lumen. While ATP can be imported from mitochondria, pyridine nucleotides are impermeable to the ER membrane, necessitating compartment-specific mechanisms to regulate NAD(H) and NADP(H) pools. Here, we demonstrate that the ER-confined pentose phosphate pathway (ER-PPP), driven by hexose-6-phosphate dehydrogenase (H6PD), processes large amounts of glucose equivalents to preserve the local redox homeostasis in triple-negative breast cancer (TNBC) cells.

Indexed as

CancerCell biologyMolecular biology

Identifiers

PMID41561377
PMCPMC12814430

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.