Evidence map›Paper›PMID 41561355›Full record

ArticleFrontiers in bioengineering and biotechnology2025

Hydrogen improves the efficacy of tetrandrine in the treatment of silicosis by inhibiting vascular endothelial mesenchymal transition caused by oxidative stress.

Kang Xiao, Ming Li, Yingwen Mu, Yuxin Sun, Sirui Wang, Shangya Chen, Jiazi Ma, Mao Cao, Yong Yang, Hua Shao and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kang XiaoSchool of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, China.
Ming LiShandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan, Shandong, China.
Yingwen MuInstitute of Toxicology, School of Public Health, Cheeloo College of Medicine, Shandong University, Ji'nan, Shandong, China.
Yuxin SunShandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan, Shandong, China.
Sirui WangCollege of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan, Shandong, China.
Shangya ChenShandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan, Shandong, China.
Jiazi MaShandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan, Shandong, China.
Mao CaoShandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan, Shandong, China.
Yong YangShandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan, Shandong, China.
Hua ShaoShandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan, Shandong, China.
Xuansheng DingSchool of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu, China.
Guanqun CuiDepartment of Respiratory Medicine, Children's Hospital Affiliated to Shandong University, Ji'nan, Shandong, China.
Zhongjun DuShandong Academy of Occupational Health and Occupational Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan, Shandong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Silicosis, a lung disease associated with occupational exposure. Tetrandrine has been approved for the treatment of silicosis in China, but it still cannot be cured. This study aims to investigate the reasons behind the low concentration of tetrandrine (Tet) in lung tissue and propose a treatment plan. Methods: We first established a silicosis mouse and employed a combination of histological examination, Western blot analysis, immunofluorescence, and single-cell RNA sequencing to clarify the relationship between oxidative stress vascular endothelial mesenchymal transition (EndMT), and Tet concentration in lung tissue. Results: The study indicated that there is excessive activation of OS and EndMT in silicosis while concurrently reducing Tet concentration in lung tissue (from 94.8 ± 10.4 ng/mg to 54 ± 6.2 ng/mg). Furthermore, combined inhalation of hydrogen (H Conclusion: Hydrogen can improve the tissue concentration of tetrandrine by anti-OS-induced EndMT.

Indexed as

EndMThydrogenoxidative stresspulmonary fibrosistetrandrine

Identifiers

PMID41561355
PMCPMC12813091

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.