ArticleFrontiers in bioengineering and biotechnology2025
Photobonding of silk fibroin-based hydrogels to rabbit corneas.
Article in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Introduction: Corneal abrasions are common ocular injuries characterized by the loss of epithelial cells. Severe cases are often treated with amniotic membrane transplantation. However, as an allogenic tissue, it can trigger immune responses, it is scarce and costly, and may require suturing to the cornea. In this study, we propose and evaluate two silk fibroin-based hydrogels implanted in rabbit corneas with a sutureless photobonding technique as a surrogate for the amniotic membrane in corneal wound healing. Methods: Silk fibroin-based hydrogels were developed with polyethylene glycol (PEG) 300 or 3350. The hydrogels were stained with 0.01% Rose Bengal and photobonded to Results: Bonding strengths measured 24- or 72-h after irradiation at 0.13 or 0.15 W/cm Conclusion: Silk fibroin-based hydrogels can be successfully bonded to
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