Evidence map›Paper›PMID 41561336›Full record

ArticleFrontiers in neurology2025

Neuropsychological and neuroimaging characteristics of patients with mild cognitive impairment and negative-amyloid deposition.

Xiangwei Dai, Junying Zhang, Xin Li, Yaojing Chen, Yanan Qiao, Shujuan Zhang, Kewei Chen, Lin Ai, Dantao Peng, Zhanjun Zhang

Abstract read
In one paragraph

Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiangwei Dai *Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
Junying Zhang *Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
Xin LiBeijing Aging Brain Rejuvenation Initiative (BABRI) Centre, Beijing Normal University, Beijing, China.
Yaojing ChenBeijing Aging Brain Rejuvenation Initiative (BABRI) Centre, Beijing Normal University, Beijing, China.
Yanan QiaoDepartment of Neurology, China-Japan Friendship Hospital, Beijing, China.
Shujuan ZhangDepartment of Neurology, China-Japan Friendship Hospital, Beijing, China.
Kewei ChenBanner Alzheimer's Institute, Phoenix, AZ, United States.
Lin AiDepartment of Nuclear Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Dantao PengDepartment of Neurology, China-Japan Friendship Hospital, Beijing, China.
Zhanjun ZhangBeijing Aging Brain Rejuvenation Initiative (BABRI) Centre, Beijing Normal University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Accumulating studies have reported that some mild cognitive impairment (MCI) patients without significant β-amyloid (Aβ) deposition on amyloid positron emission tomography (PET) can later develop Alzheimer's disease (AD). Therefore, this study profiled the cognitive and neural characteristics of MCI patients with negative Aβ deposition to better understand potential features associated with an increased risk of AD progression. Methods: Thirty-seven MCI patients and 32 normal controls (NCs) underwent neuropsychological assessments, structural magnetic resonance imaging, and diffusion tensor imaging scans. MCI patients were stratified into amyloid-positive (Aβ Results: Cognitively, relative to NCs, participants in Aβ Conclusion: Aβ

Indexed as

Alzheimer’s diseaseamyloid depositiongray matter atrophymild cognitive impairmentwhite matter disruption

Identifiers

PMID41561336
PMCPMC12812577

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.