Evidence map›Paper›PMID 41561326›Full record

ArticleFrontiers in neurology2025

Association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and cognitive impairment in patients with cerebral small vessel disease.

Chao Wang, Zhenjie Teng, Mingyue Fan, Xiaohua Xie, Weihong Chen, Yueshan Zhao, Jiayu Zhang, Yanhong Dong, Jing Xu, Wei Jin and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chao WangDepartment of Neurology, Graduate School of North China University of Science and Technology, Tangshan, China.
Zhenjie TengDepartment of Neurology, Hebei General Hospital, Shijiazhuang, China.
Mingyue FanDepartment of Neurology, Hebei General Hospital, Shijiazhuang, China.
Xiaohua XieDepartment of Neurology, Hebei General Hospital, Shijiazhuang, China.
Weihong ChenDepartment of Neurology, Hebei General Hospital, Shijiazhuang, China.
Yueshan ZhaoDepartment of Neurology, Hebei General Hospital, Shijiazhuang, China.
Jiayu ZhangDepartment of Neurology, Hebei General Hospital, Shijiazhuang, China.
Yanhong DongDepartment of Neurology, Hebei General Hospital, Shijiazhuang, China.
Jing XuDepartment of Neurology, Hebei General Hospital, Shijiazhuang, China.
Wei JinDepartment of Neurology, Hebei General Hospital, Shijiazhuang, China.
Peiyuan LvDepartment of Neurology, Hebei General Hospital, Shijiazhuang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study aims to determine the potential association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and cognitive impairment in patients with cerebral small vessel disease (CSVD). By collecting data from patients with CSVD in hospital, we will analyze the relationship between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and cognitive function in these patients. Methods: This study enrolled 263 CSVD patients, Cognitive function was assessed using Mini-Mental State Examination (MMSE) within 2 weeks, with cognitive impairment defined by education stratified thresholds. Statistical analysis of the baseline was performed. The association between NHHR and cognitive function was evaluated using binary logistic regression. And Receiver Operating Characteristic Curve (ROC) analysis were performed to evaluate the predictive value. Results: Patients were classified into cognitive impairment group ( Conclusion: NHHR serves as an independent predictor of cognitive impairment in CSVD patients. The NHHR-derived model exhibits moderate discriminative accuracy, indicating potential clinical applicability.

Indexed as

cerebral small vessel diseasecognitive impairmenthigh-density lipoprotein cholesterolnon-high-density lipoprotein cholesterolnon-high-density lipoprotein cholesterol to HDL-C ratio

Identifiers

PMID41561326
PMCPMC12812587

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.